A container and closure combination, for the containment of fluids and extraction therefrom by way of an extraction tube. The container comprises a closed volume with an opening configured to close the opening of the container; the closure is provided with an aperture such that the closure, upon fitment to the container opening, cannot be removed therefrom. The aperture of the closure comprises a unitary elastic unidirectional valve member that can operate in a first, closed condition, to prevent a flow of fluid from the container; and a second, operational condition, with an extraction tube sealingly engaged with respect to the valve, to permit an extraction of fluid from the container through the tube.

A container and closure combination, for the containment of fluids and extraction therefrom by way of an extraction tube. The container comprises a closed volume with an opening configured to close the opening of the container; the closure is provided with an aperture such that the closure, upon fitment to the container opening, cannot be removed therefrom. The aperture of the closure comprises a unitary elastic unidirectional valve member that can operate in a first, closed condition, to prevent a flow of fluid from the container; and a second, operational condition, with an extraction tube sealingly engaged with respect to the valve, to permit an extraction of fluid from the container through the tube.

A container and closure combination, for the containment of fluids and extraction therefrom by way of an extraction tube. The container comprises a closed volume with an opening configured to close the opening of the container; the closure is provided with an aperture such that the closure, upon fitment to the container opening, cannot be removed therefrom. The aperture of the closure comprises a unitary elastic unidirectional valve member that can operate in a first, closed condition, to prevent a flow of fluid from the container; and a second, operational condition, with an extraction tube sealingly engaged with respect to the valve, to permit an extraction of fluid from the container through the tube.

A container and closure combination, for the containment of fluids and extraction therefrom by way of an extraction tube. The container comprises a closed volume with an opening configured to close the opening of the container; the closure is provided with an aperture such that the closure, upon fitment to the container opening, cannot be removed therefrom. The aperture of the closure comprises a unitary elastic unidirectional valve member that can operate in a first, closed condition, to prevent a flow of fluid from the container; and a second, operational condition, with an extraction tube sealingly engaged with respect to the valve, to permit an extraction of fluid from the container through the tube.

An apparatus for collecting and storing fluid samples from vehicles and machinery comprises a storage container having a fluid inlet sealed by a cap, the cap having an aperture releasably sealed by a lid. An adapter connects the cap releasably to a fluid outlet coupling port of a fluid sampling device. The adapter comprises a lumen, having an inlet and an outlet aperture, an external screw thread engageable with an internal screw thread of the coupling port and a connector assembly for connecting the adapter releasably to the cap. A penetrable diaphragm provides an airtight seal over a storage region of the storage container. When the adapter is connected to the coupling port and the cap is connected to the adapter, a fluid outlet tube extending from the coupling port extends through the aperture and protrudes through one or more perforations provided in the penetrable diaphragm into the storage region.

An apparatus for collecting and storing fluid samples from vehicles and machinery comprises a storage container having a fluid inlet sealed by a cap, the cap having an aperture releasably sealed by a lid. An adapter connects the cap releasably to a fluid outlet coupling port of a fluid sampling device. The adapter comprises a lumen, having an inlet and an outlet aperture, an external screw thread engageable with an internal screw thread of the coupling port and a connector assembly for connecting the adapter releasably to the cap. A penetrable diaphragm provides an airtight seal over a storage region of the storage container. When the adapter is connected to the coupling port and the cap is connected to the adapter, a fluid outlet tube extending from the coupling port extends through the aperture and protrudes through one or more perforations provided in the penetrable diaphragm into the storage region.

Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.

A cap assembly includes a base cap, a chemical resistant sheet, and a closure assembly. The closure assembly is configured for carrying the chemical resistant sheet. The closure assembly is mounted in the base cap. The base cap and the closure assembly together define a central cap assembly aperture therethrough.

A fitting for affixing to a mouth of a receiving container comprises a tubular body having a closed top end, a bottom end and a side wall extending between the closed top and bottom ends and having an inner surface and an outer surface. The inner surface includes a circumferential surface wherein the circumferential surface includes a plurality of inwardly extending, randomly placed nodes to engage an external surface of the mouth of the receiving container. A plug seal extending from the closed top end is spaced apart from circumferential surface to form a land area seal. The closed top end may further include an aperture adapted to permit passage of a straw therethrough.

A fitting for affixing to a mouth of a receiving container comprises a tubular body having a closed top end, a bottom end and a side wall extending between the closed top and bottom ends and having an inner surface and an outer surface. The inner surface includes a circumferential surface wherein the circumferential surface includes a plurality of inwardly extending, randomly placed nodes to engage an external surface of the mouth of the receiving container. A plug seal extending from the closed top end is spaced apart from circumferential surface to form a land area seal. The closed top end may further include an aperture adapted to permit passage of a straw therethrough.