Disclosed herein are systems and methods for inducing a substantially non-hazardous atmosphere encompassing a beverage container during filling, such as filling a small volume container with an alcohol product. A multi-tiered approach can be used to reduce the combustibility of the atmosphere encompassing the beverage container. For example, a ventilation module can be provided and configured to dilute vapors of the beverage liquid. Further, a chilling module can be provided and configured to reduce or maintain a reduced temperature of the beverage liquid. Further, a capture module can be provided and configured to dilute stray beverage liquid. The ventilation module, the chilling module, and the capture module can cooperate to define a non-hazardous zone encompassing the beverage container. This can allow non-hazardous rated electrical components to operate proximate and within the atmosphere associating the alcohol product during filling.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

A “smart” closure system, apparatus, and method are described. The closure includes mechanical solution, used in conjunction with wireless technologies and/or web-based or remote authentication, verification, and serialization via a mobile computing device, to provide information about the closure and the contents concealed within that closure. Further, the construction of the closure allows for any and all non-recyclable components of the wireless technologies to be removed so as to enable the closure to be recycled and/or converted to post consumer resin.

A cap for an applicator includes an inlet, a base having a connection portion embodied for connecting the cap to the applicator or a container formed therein, a head that receives an application part of the applicator within the head, and a projection formed at a top part of the cap. The top part formed at an opposite end to the inlet, and the projection cooperating with an outlet of the applicator. The head includes a cylindrical or conical inner or outer shape and the connection portion has a round inner or outer shape, that is an oval, round or square shape.

A cap for an applicator includes an inlet, a base having a connection portion embodied for connecting the cap to the applicator or a container formed therein, a head that receives an application part of the applicator within the head, and a projection formed at a top part of the cap. The top part formed at an opposite end to the inlet, and the projection cooperating with an outlet of the applicator. The head includes a cylindrical or conical inner or outer shape and the connection portion has a round inner or outer shape, that is an oval, round or square shape.

A cap assembly for closing an opening in a vessel may include a stopper and a rigid cap adapted to fit over the stopper and onto a vessel. The stopper may include a polymer body adapted to fit an opening of the vessel and a tubular portion defining an internal passageway extending through the polymer body. The rigid cap may include a pressure based locking mechanism adapted to engage the vessel under a unidirectional force and a tamper evident feature.

A cap assembly for closing an opening in a vessel may include a stopper and a rigid cap adapted to fit over the stopper and onto a vessel. The stopper may include a polymer body adapted to fit an opening of the vessel and a tubular portion defining an internal passageway extending through the polymer body. The rigid cap may include a pressure based locking mechanism adapted to engage the vessel under a unidirectional force and a tamper evident feature.

A “smart” closure system, apparatus, and method are described. The closure includes mechanical solution, used in conjunction with wireless technologies and/or web-based or remote authentication, verification, and serialization via a mobile computing device, to provide information about the closure and the contents concealed within that closure. Further, the construction of the closure allows for any and all non-recyclable components of the wireless technologies to be removed so as to enable the closure to be recycled and/or converted to post consumer resin.

Caps for sealing assemblies for sealing glass containers and maintaining container closure integrity at −80° C. or less are disclosed. The caps include a cap skirt having an annular body and a crimp region. The crimp region is a crimpable metal. The annular body of the cap skirt has a coefficient of thermal expansion (CTE) greater than a CTE of a metal consisting of aluminum, a stiffness greater than or equal to 2 times a stiffness of the crimp region, or both. The greater CTE, stiffness, or both of the cap skirt increase the seal pressure and contact area between the stopper and glass container when cooled to −80° C. or less. The caps enable the sealing assemblies to maintain a helium leakage rate of the sealed glass container of less than or equal to 1.4×10.sup.−6 cm.sup.3/s at −80° C. or less.