In some embodiments, systems and methods are provided that limit the change in temperature and/or control a temperature of a product during delivery. Some embodiments provide systems to limit temperature changes of a product during transit, comprising: aerosol temperature control system comprising a product holder configured to support a product, wherein the product holder is separate from the delivery vehicle and comprises a temperature sensor, and an aerosol dispenser system that comprises a reservoir configured to hold aerosol material, an actuator and a dispenser; and a temperature control circuit coupled with the temperature sensor and the actuator, wherein the temperature control circuit is configured to receive temperature data, determine based on current temperature data that a temperature of the first product is greater than a first transport temperature threshold, and to autonomously activate the actuator while the first product is in transit.

A non-electrically powered automatic dosing and spraying valve assembly for a container of pressurized fluid with an outlet valve is described, wherein the valve assembly comprises a housing containing at least two chambers wherein one of those chambers is a main chamber open at one end to the contents of the container and closed at one end by a movable plunger, and another of those chambers is a dose chamber closed at one end by the movable plunger and closed at the other end by a prodder seal formed between a movable prodder and a fluid outlet opening; wherein the movable plunger is biased against movement toward the dose chamber by a main spring means and a prodder spring means, the main spring means being mounted in or adjacent to the dose chamber and the prodder spring means being connected to both the movable plunger and movable prodder, the assembly further comprises a fluid leak path between the main chamber and the dose chamber; and wherein the assembly is arranged such that, in use, one movable component of the assembly is configured to move relative to another component of the assembly to temporarily expose the dose chamber to the full fluid pressure of the main chamber.

The present invention provides an agent dispenser for use in introducing an agent into a fluid where the agent is miscible with such fluid. The agent dispenser comprises a hollow casing constructed of a material having a coefficient of cubical expansion that differs from the coefficient of cubical expansion of the fluid. At least one opening is provided in the hollow casing for permitting the flow of the fluid to and from the interior of the hollow casing. The opening is provided with a tube sealed in the opening, one end of the tube being contained within the hollow casing and the second end of the tube being exterior to the hollow casing for communication with the surrounding fluid. The second end of the tube is provided with a filter membrane having a defined pore size to prevent any debris which may be present in the fluid from blocking the second end or entering the hollow casing. The dispenser contains the agent and the agent is introduced into the fluid through fluid drawn into and expelled from said dispenser as a result of variations in the internal pressure of the dispenser resulting from thermal expansion and contraction of the dispenser and its contents caused by variations in the temperature of the fluid surrounding the dispenser.

A refill assembly (129) for use in a medicinal inhaler (100). The refill assembly includes a patient port (110), and an adapter (118) configured to cause a dose of medicament to be released. The adapter is movable between a first position in which a dose of medicament is not released and a second position in which a dose of medicament is released. The refill assembly further includes a lockout member (117) movable between (i) a first (locked) position in which the adapter is not movable from its first position to its second position, and (ii) a second (unlocked) position in which the adapter is movable from its first position to its second position.

An aerosol dispensing device includes an atomizer configured to atomize a liquid contained in a cartridge, an actuator configured to actuate activity of the atomizer, a reader configured to read data attached to the cartridge while the cartridge is installed in the device and a controller. The controller is configured to receive data from the reader, verify authenticity of the cartridge based on the data received, initiate activity of the actuator based on verifying that the cartridge is authentic, and block activity of the actuator based on verifying that the cartridge is not authentic.

The present invention provides an agent dispenser for use in introducing an agent into a fluid where the agent is miscible with such fluid. The agent dispenser comprises a hollow casing constructed of a material having a coefficient of cubical expansion that differs from the coefficient of cubical expansion of the fluid. At least one opening is provided in the hollow casing for permitting the flow of the fluid to and from the interior of the hollow casing. The opening is provided with a tube sealed in the opening, one end of the tube being contained within the hollow casing and the second end of the tube being exterior to the hollow casing for communication with the surrounding fluid. The second end of the tube is provided with a filter membrane having a defined pore size to prevent any debris which may be present in the fluid from blocking the second end or entering the hollow casing. The dispenser contains the agent and the agent is introduced into the fluid through fluid drawn into and expelled from said dispenser as a result of variations in the internal pressure of the dispenser resulting from thermal expansion and contraction of the dispenser and its contents caused by variations in the temperature of the fluid surrounding the dispenser.

The present disclosure relates to aerosol delivery devices, elements of such devices, and methods for producing vapor. In some embodiments, the present disclosure provides devices configured for vaporization of an aerosol precursor composition that is contained in and transported to a heating element by a unitary reservoir and liquid transport element. The unitary reservoir and liquid transport element may include a porous monolith.

A refill assembly (129) for use in a medicinal inhaler (100). The refill assembly includes a patient port (110), and an adapter (118) configured to cause a dose of medicament to be released. The adapter is movable between a first position in which a dose of medicament is not released and a second position in which a dose of medicament is released. The refill assembly further includes a lockout member (117) movable between (i) a first (locked) position in which the adapter is not movable from its first position to its second position, and (ii) a second (unlocked) position in which the adapter is movable from its first position to its second position.

An aerosol dispensing device includes an atomizer configured to atomize a liquid contained in a cartridge, an actuator configured to actuate activity of the atomizer, a reader configured to read data attached to the cartridge while the cartridge is installed in the device and a controller. The controller is configured to receive data from the reader, verify authenticity of the cartridge based on the data received, initiate activity of the actuator based on verifying that the cartridge is authentic, and block activity of the actuator based on verifying that the cartridge is not authentic.

The present disclosure relates to aerosol delivery devices, elements of such devices, and methods for producing vapor. In some embodiments, the present disclosure provides devices configured for vaporization of an aerosol precursor composition that is contained in and transported to a heating element by a unitary reservoir and liquid transport element. The unitary reservoir and liquid transport element may include a porous monolith.