A solution bottle contains: a body and an applying head. The body includes a holder, a first sleeve, and a second sleeve. The holder has an accommodation chamber configured to accommodate a spray can, the first sleeve is secured on a top of the holder, and the second sleeve is connected with an inner wall of the first sleeve. The second sleeve has a connection hole arranged on a bottom thereof and fitting with the spray can, and the second sleeve has a receiving groove configured to house the applying head and communicating with the fitting hole. Thereby, the solution bottle is capable of massaging and applying the solution (such as medicine agent or cosmetics) on the user's body.

The invention relates to a dispensing system for use in cryogenic skin treatment that is capable of targeted delivery of a cryogen at a high rate, thereby achieving rapid freezing of targeted skin tissue. The dispensing system of the present invention uses a cryogen that contains dimethyl ether and is designed to deliver the cryogen in an accurate and very effective manner.

Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter. The process throughput is very high, reaching several thousands of particles with liquid micro-shells per second for one blowing nozzle. The generated aerosol particles are extremely light-weight (few micrograms) and have very small wall thickness (couple of microns), which enables precise delivery of materials and rapid evaporation of solvent in their liquid walls. The process production rate is easily scalable. In terms of possible applications, liquid used for aerosol generation can be enriched with suspended or dissolved materials, for instance by a medical drug for direct delivery into a patient's airways, or by organic/inorganic solvent which solidifies during drying enabling formation of soft or rigid spherical shells out of particles with liquid shells. The blowing gas can have suspended micron/nano particles in it and these particles will be encapsulated by liquid walls of formed micro-shells, which can potentially solidify during their motion, and thus produced aerosols can be used as transport agents for material delivery. Formation of fine monodisperse liquid or solid foams is possible by collecting liquid micro-shells from the generated aerosol on a surface or in a vessel, while the liquid walls of particles of adhere to each other and then can solidify due to solvent evaporation, freezing or polymerization.

Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter. The process throughput is very high, reaching several thousands of particles with liquid micro-shells per second for one blowing nozzle. The generated aerosol particles are extremely light-weight (few micrograms) and have very small wall thickness (couple of microns), which enables precise delivery of materials and rapid evaporation of solvent in their liquid walls. The process production rate is easily scalable. In terms of possible applications, liquid used for aerosol generation can be enriched with suspended or dissolved materials, for instance by a medical drug for direct delivery into a patient's airways, or by organic/inorganic solvent which solidifies during drying enabling formation of soft or rigid spherical shells out of particles with liquid shells. The blowing gas can have suspended micron/nano particles in it and these particles will be encapsulated by liquid walls of formed micro-shells, which can potentially solidify during their motion, and thus produced aerosols can be used as transport agents for material delivery. Formation of fine monodisperse liquid or solid foams is possible by collecting liquid micro-shells from the generated aerosol on a surface or in a vessel, while the liquid walls of particles of adhere to each other and then can solidify due to solvent evaporation, freezing or polymerization.

A device for dispensing a material includes a reservoir for the material and an outlet channel connectable thereto. The reservoir has a tubular body partially filled with pressurized gas and partially filled with the material to be dispensed. One end of the tubular body is welded shut and an opposite end is closed by a sealing member extending over at least part of a cross-sectional area of the tubular body. The sealing member is arranged in a sleeve connected to the end of the tubular body opposite the welded end thereof. The sealing member has a pierceable diaphragm and the device may further comprise a piercing member. The sealing member can include a movable valve or can be removably fixed inside the tubular body and the device can include an operating member. The tubular body and the piercing member or operating member, respectively, may be movable towards each other.

An activator for use with an aerosol spray can is presented having a two-part housing formed from a first side and a second side that when aligned and connected together retains a trigger that is pivotally attached to one of the first and second sides. Snap fittings or a can adjuster can be used to slidably engage with the spray can to securely hold the spray can and preventing axial movement relative to the housing. A nozzle elbow is movable contained within the housing having a distal end and a proximal end, where the proximal end accepts and operatively connects with a valve stem on the spray can. A spray head is releasably positioned in the distal end of the elbow nozzle.

An activator for use with an aerosol spray can is presented having a two-part housing formed from a first side and a second side that when aligned and connected together retains a trigger that is pivotally attached to one of the first and second sides. Snap fittings or a can adjuster can be used to slidably engage with the spray can to securely hold the spray can and preventing axial movement relative to the housing. A nozzle elbow is movable contained within the housing having a distal end and a proximal end, where the proximal end accepts and operatively connects with a valve stem on the spray can. A spray head is releasably positioned in the distal end of the elbow nozzle.

A pressurized container assembly includes a pressurized container, a valve, and a shearing chamber. A flowable product and propellant are also provided within the container. The propellant is substantially non-soluble in the flowable product. Methods of producing a foamed flowable product using shearing chambers are also disclosed.

A pressurized container assembly includes a pressurized container, a valve, and a shearing chamber. A flowable product and propellant are also provided within the container. The propellant is substantially non-soluble in the flowable product. Methods of producing a foamed flowable product using shearing chambers are also disclosed.

A system is described for the hands-free administration of a nutritional supplement matrix to the oral mucosa. A two-piece mouthpiece is formed in a nozzle cap that accepts canisters with the nutritional supplement matrix under pressure. Bite pressure administered by a user to an upper moveable portion of the two-piece mouthpiece may activate the dispensing of an atomized mixture of the nutritional supplement matrix. A flexible joiner between the upper moveable portion and the lower fixed portion of the two-piece mouthpiece may compress, fold, or otherwise collapse under the bite pressure from the user.