The present disclosure provides an apparatus for manufacturing a superfine fiber roll wiper for a cleanroom, wherein a thermal cutting unit including thermal cutting blocks and thermal cutters is applied to a thermal cutting part, such that a process of manufacturing a roll wiper and a process of thermally bonding both ends of the manufactured roll wiper may be performed by the single apparatus, as a result of which, with the use of the single apparatus, it is possible to considerably improve workability, implement the mass-production, and reduce manufacturing costs. Further, the thermal cutting unit further including interval adjustment blocks in addition to the thermal cutting blocks and the thermal cutters is applied, such that a width of a roll wiper to be manufactured may be selectively and conveniently adjusted when a change in width of the roll wiper is required.