Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.

A filling element includes a liquid valve having a valve element that forms part of the liquid channel. An electromagnetic drive couples to the valve element and moves it along a stroke axis such that the valve element moves while a valve body remains stationary. A gap across which the magnetic field extends lies outside the liquid channel.

A sterilization line comprising upstream-side and downstream-side tanks for storing liquid which are connected by a conduit for transferring the liquid, holding tubes for sterilizing the liquid which are disposed in an intermediate section of the conduit, heating units for heating the liquid in stages which are disposed in a section of the conduit from the upstream-side tank to the holding tubes, and cooling units for cooling the product liquid in stages which are disposed in a section of the conduit from the holding tubes to the downstream-side tank. A swing bend is used to perform switching between a section of a liquid flow path located on the upstream side of multiple intermediate piping systems and a cleaning solution path for a cleaning-in-place operation and switching between a section of the liquid flow path located on the downstream side and the cleaning solution path for the cleaning-in-place operation.

An apparatus for filling containers comprises a filling station, with a plurality of filling heads which are supplied by supply ducts supplying a filling fluid and are each provided with a dispensing nozzle. The apparatus has a number of collection cups for collecting washing fluids for washing the filling heads and the supply ducts, equal to the number of said filling heads.

A sterilization line comprising upstream-side and downstream-side tanks for storing liquid which are connected by a conduit for transferring the liquid, holding tubes for sterilizing the liquid which are disposed in an intermediate section of the conduit, heating units for heating the liquid in stages which are disposed in a section of the conduit from the upstream-side tank to the holding tubes, and cooling units for cooling the product liquid in stages which are disposed in a section of the conduit from the holding tubes to the downstream-side tank. A swing bend is used to perform switching between a section of a liquid flow path located on the upstream side of multiple intermediate piping systems and a cleaning solution path for a cleaning-in-place operation and switching between a section of the liquid flow path located on the downstream side and the cleaning solution path for the cleaning-in-place operation.

A filling element for filling containers includes a liquid valve disposed to control flow into the container. The valve has an elastic diaphragm and a valve surface. An actuator causes the diaphragm to transition between a first state, in which it butts against the valve surface, and a second state, in which it is spaced apart from the valve surface.

A filling system includes filling elements, each of which has a channel formed in its housing. During filling, filling material, under a liquid valve's control, passes through the channel and exits through an opening and into a container held on a vertically displaceable container carrier. During pressure filling, the container carrier seals the container against the filling element. During cleaning and sterilization, rinsing caps seal each opening. Each filling element is associated with an extension that seals the outlet. Each extension has a filling-material through-passage that, when the extension is sealed against said outlet, extends the filling-material channel.

An automatic juice packaging device including an automatic door sheet, an automatic cupping device and an automatic juice-out device. The automatic cupping device includes a base plate, a cup discharging device, a cover discharging device, and a cover pressing device. The cup discharging device, the cover discharging device and the cover pressing device are higher than the base plate, the base plate is connected to a motor, and the motor drives the base plate to rotate around the center of circle. The automatic juice-out device includes a funnel, a juice storage tube, a connecting piece, and a guide tube connected to the bottom of the funnel. One end of the juice storage tube is closed, and the other end is provided with an opening. The bottom of the guide tube is located in the opening at the upper part of the middle of the juice storage tube.

A filling element includes a liquid valve having a valve element that forms part of the liquid channel. An electromagnetic drive couples to the valve element and moves it along a stroke axis such that the valve element moves while a valve body remains stationary. A gap across which the magnetic field extends lies outside the liquid channel.

Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.