Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.

Apparatuses and methods for production of molybdenum targets, and the formed molybdenum targets, used to produce Tc-99m are described. The target includes a copper support plate having a front face and a back face. The copper support plate desirably has dimensions of thickness of about 2.8 mm, a length of about 65 mm and a width of about 30 mm; and the copper support plate desirably has either a circular or an elliptical cavity centrally formed therein by pressing molybdenum powder into the front face with a depth of about 200-400 microns. Also, the copper support plate includes cooling channels dispensed at the back face; wherein the copper support plate is water cooled by a flow of water during irradiation by a proton beam. Molybdenum powder is embedded and compressed onto the cavity of the copper support plate thereby creating a thin layer of molybdenum onto the copper support plate.

Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.

Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.

A mixed conductor represented by Formula 1:
A.sub.4+xM.sub.5-yM′.sub.yO.sub.12-δ,  Formula 1
wherein, in Formula 1, A is a monovalent cation, M is at least one of a divalent cation, a trivalent cation, or a tetravalent cation, M′ is at least one of a monovalent cation, a divalent cation, a trivalent cation, a tetravalent cation, a pentavalent cation, or a hexavalent cation, M and M′ are different from each other, and 0.3≤x<3, 0.01<y<2, and 0≤δ≤1 are satisfied.

A process for the separation of .sup.99mTc from molybdenum targets is described. The method for separation of .sup.99mTc isotope from molybdenum targets includes: i) providing an initial multicomponent mixture of elements, the mixture containing .sup.99mTc; ii) dissolving the multicomponent mixture of elements with an oxidizing agent to oxidize the mixture of elements; iii) heating the mixture of elements at a temperature sufficiently high enough to sublimate a vaporized compound containing .sup.99mTc; iv) condensing the vaporized compound containing .sup.99mTc to form a reaction product; v) adding a base to the condensed reaction product to dissolve the .sup.99mTc containing reaction product to form sodium pertechnetate (Na.sup.99mTcO.sub.4); and vii) purifying the crude solution of sodium pertechnetate Na.sup.99mTcO.sub.4 using column chromatography to provide the .sup.99mTc isotope as a radiochemical compound.

A process for the separation of .sup.99mTc from molybdenum targets is described. The method for separation of .sup.99mTc isotope from molybdenum targets includes: i) providing an initial multicomponent mixture of elements, the mixture containing .sup.99mTc; ii) dissolving the multicomponent mixture of elements with an oxidizing agent to oxidize the mixture of elements; iii) heating the mixture of elements at a temperature sufficiently high enough to sublimate a vaporized compound containing .sup.99mTc; iv) condensing the vaporized compound containing .sup.99mTc to form a reaction product; v) adding a base to the condensed reaction product to dissolve the .sup.99mTc containing reaction product to form sodium pertechnetate (Na.sup.99mTcO.sub.4); and vii) purifying the crude solution of sodium pertechnetate Na.sup.99mTc04 using column chromatography to provide the .sup.99mTc isotope as a radiochemical compound.

Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.

Apparatuses and methods for production of molybdenum targets, and the formed molybdenum targets, used to produce Tc-99m are described. The target includes a copper support plate having a front face and a back face. The copper support plate desirably has dimensions of thickness of about 2.8 mm, a length of about 65 mm and a width of about 30 mm; and the copper support plate desirably has either a circular or an elliptical cavity centrally formed therein by pressing molybdenum powder into the front face with a depth of about 200-400 microns. Also, the copper support plate includes cooling channels dispensed at the back face; wherein the copper support plate is water cooled by a flow of water during irradiation by a proton beam. Molybdenum powder is embedded and compressed onto the cavity of the copper support plate thereby creating a thin layer of molybdenum onto the copper support plate.

Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.