A glass container that includes a base defining a hole, and methods of manufacturing and using the glass container, is disclosed. The glass container is manufactured by providing the container and cutting a hole in a wall of the container. The hole may be cut into the wall by any technique in which glass material is separated from the wall including by mechanical shearing, thermal energy, and/or fluid impingement. To use the glass container, a deformable blow-out plug may be inserted into the hole to fluidly seal the hole, a liquid beverage may be introduced into the container, a closure may be coupled to the container to close the container and provide a pressurizable package, and thereafter the package may be internally pressurized by introducing a pressurizing gas into the package.

A glass vial includes a base including a boron-containing multicomponent glass and a vial opening and holds a liquid active pharmaceutical ingredient formulation. The glass vial has a total volume of <4.5 mL. A filling level of the glass vial with the active pharmaceutical ingredient formulation is not more than 0.25 and a concentration of boron ions, measured at a measurement site below a plane of a middle of the glass vial using a concentration depth profile at a depth in a range from 10 to 30 nm, has a value, averaged over the measurements of the concentration depth profile, that has an excess increase of not more than 30% compared to a concentration of boron ions measured using a concentration depth profile at a depth in a range from 10 to 30 nm with a measurement site in the plane of the middle of the glass vial.

A glass vial includes a base including a boron-containing multicomponent glass and a vial opening and holds a liquid active pharmaceutical ingredient formulation. The glass vial has a total volume of <4.5 mL. A filling level of the glass vial with the active pharmaceutical ingredient formulation is not more than 0.25 and a concentration of boron ions, measured at a measurement site below a plane of a middle of the glass vial using a concentration depth profile at a depth in a range from 10 to 30 nm, has a value, averaged over the measurements of the concentration depth profile, that has an excess increase of not more than 30% compared to a concentration of boron ions measured using a concentration depth profile at a depth in a range from 10 to 30 nm with a measurement site in the plane of the middle of the glass vial.

A method of forming a glass vial includes: locally heating one end of a glass tube; removing the locally heated end of the glass tube to form the glass vial having a closed base; and further forming the base of the glass vial, the further forming including generating a purge gas flow within the formed glass vial with the aid of a purge gas.

A method of forming a glass vial includes: locally heating one end of a glass tube; removing the locally heated end of the glass tube to form the glass vial having a closed base; and further forming the base of the glass vial, the further forming including generating a purge gas flow within the formed glass vial with the aid of a purge gas.

Provided is a method for manufacturing a glass container with which a glass container having a distinctively shaped inner space and excellent aesthetic appearance can be manufactured in good yield. The method for manufacturing a glass container includes steps (A) to (E). (A) A step of introducing a gob into a mold through a funnel. (B) A step of blowing air into the mold through the funnel, bringing a plunger disposed on a side opposite the side to which the funnel is fitted in contact with the gob, separating the plunger from the gob, and forming a recess on the surface of the gob. (C) A step of removing the funnel from the mold and fitting a baffle to the mold. (D) A step of blowing air from the plunger, and forming an inner space inside the gob with the recess as a starting point while simultaneously forming an outer shape by pressing the outer side of the gob to a molding surface of the mold to obtain a glass container of the final shape. (E) A step of transferring the glass container of the final shape to a cooling mold and cooling the same.

Provided is a method for manufacturing a glass container with which a glass container having a distinctively shaped inner space and excellent aesthetic appearance can be manufactured in good yield. The method for manufacturing a glass container includes steps (A) to (E). (A) A step of introducing a gob into a mold through a funnel. (B) A step of blowing air into the mold through the funnel, bringing a plunger disposed on a side opposite the side to which the funnel is fitted in contact with the gob, separating the plunger from the gob, and forming a recess on the surface of the gob. (C) A step of removing the funnel from the mold and fitting a baffle to the mold. (D) A step of blowing air from the plunger, and forming an inner space inside the gob with the recess as a starting point while simultaneously forming an outer shape by pressing the outer side of the gob to a molding surface of the mold to obtain a glass container of the final shape. (E) A step of transferring the glass container of the final shape to a cooling mold and cooling the same.

A glass vial includes a base including a boron-containing multicomponent glass and a vial opening and holds a liquid active pharmaceutical ingredient formulation. The glass vial has a total volume of <4.5 mL. A filling level of the glass vial with the active pharmaceutical ingredient formulation is not more than 0.25 and a concentration of boron ions, measured at a measurement site below a plane of a middle of the glass vial using a concentration depth profile at a depth in a range from 10 to 30 nm, has a value, averaged over the measurements of the concentration depth profile, that has an excess increase of not more than 30% compared to a concentration of boron ions measured using a concentration depth profile at a depth in a range from 10 to 30 nm with a measurement site in the plane of the middle of the glass vial.

A glass vial includes a base including a boron-containing multicomponent glass and a vial opening and holds a liquid active pharmaceutical ingredient formulation. The glass vial has a total volume of <4.5 mL. A filling level of the glass vial with the active pharmaceutical ingredient formulation is not more than 0.25 and a concentration of boron ions, measured at a measurement site below a plane of a middle of the glass vial using a concentration depth profile at a depth in a range from 10 to 30 nm, has a value, averaged over the measurements of the concentration depth profile, that has an excess increase of not more than 30% compared to a concentration of boron ions measured using a concentration depth profile at a depth in a range from 10 to 30 nm with a measurement site in the plane of the middle of the glass vial.

The invention relates to a method of fabricating a glass container, the method comprising a forming step of forming molten glass in order to obtain a semi-finished container (4) comprising a shell (5) presenting inside and outside faces (7, 8), a cooling step during which the semi-finished container is in a transient state in which the glass forming the outside face is sufficiently viscous for it not to deform under the effect of gravity, while the glass forming the inside face is sufficiently fluid to allow the inside face to deform under the effect of gravity, the method including a shaping operation while the semi-finished container is in the transient state, in which operation the semi-finished container is maintained for a predetermined time in a position that is inclined relative to its upright vertical position in order to modify the shape of the inside face under the effect of gravity.