A process for the preparation of 1-bromo-2,4,5-trifluorobenzene from 2,4,5-trifluoroaniline or sulfate salt thereof.

##STR00001##

##STR00002##

A process for the preparation of 1 ,2,4-trifluorobenzene from 2,4,5-trifluoroaniline and then converting into 1-bromo-2,4,5-trifluorobenzene.

A process for the preparation of 1-bromo-2,4,5-trifluorobenzene from 2,4,5-trifluoroaniline or sulfate salt thereof.

##STR00001##

##STR00002##

A process for the preparation of 1 ,2,4-trifluorobenzene from 2,4,5-trifluoroaniline and then converting into 1-bromo-2,4,5-trifluorobenzene.

The invention relates to a process for the preparation of compound of formula (I) wherein R.sub.1 is halogen and R.sub.2 is halogen or hydrogen; comprising a) reacting the compound of formula (II) in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent, to the compound of formula I wherein R.sub.1 is halogen and R.sub.2 is hydrogen, and b) reacting the compound of formula (I), wherein R.sub.1 is chloro and R.sub.2 is hydrogen, in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent to a compound of formula I, wherein R.sub.1 is chloro and R.sub.2 is halogen.

##STR00001##

The invention relates to a process for the preparation of compound of formula (I) wherein R.sub.1 is halogen and R.sub.2 is halogen or hydrogen; comprising a) reacting the compound of formula (II) in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent, to the compound of formula I wherein R.sub.1 is halogen and R.sub.2 is hydrogen, and b) reacting the compound of formula (I), wherein R.sub.1 is chloro and R.sub.2 is hydrogen, in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent to a compound of formula I, wherein R.sub.1 is chloro and R.sub.2 is halogen.

##STR00001##

An adsorptive separation process and system are used for separation of multi-component fluid mixtures. The separation process and system may include establishing, in a fluid flow within the system, a concentration distribution of the fluid mixture components based upon the components' relative affinities to the adsorbent. The concentration distribution could be establishing using a simulated moving bed system, wherein it is possible to maintain separately-identifiable portions of the fluid flow, respectively rich in strongly-adsorbing, intermediately-adsorbing, and weakly-adsorbing compounds of the fluid mixture. An intermediate raffinate of high purity in the intermediately-adsorbing compound is directly withdrawn from the portion of the fluid flow rich in intermediately-adsorbing compound(s), providing a single-stage adsorptive separation of a compound having intermediate affinity to the adsorbent. The portion of the fluid flow rich in intermediately-adsorbing compound(s) may be established directly upstream from the point of fluid mixture feed injection into the fluid flow.

An adsorptive separation process and system are used for separation of multi-component fluid mixtures. The separation process and system may include establishing, in a fluid flow within the system, a concentration distribution of the fluid mixture components based upon the components' relative affinities to the adsorbent. The concentration distribution could be establishing using a simulated moving bed system, wherein it is possible to maintain separately-identifiable portions of the fluid flow, respectively rich in strongly-adsorbing, intermediately-adsorbing, and weakly-adsorbing compounds of the fluid mixture. An intermediate raffinate of high purity in the intermediately-adsorbing compound is directly withdrawn from the portion of the fluid flow rich in intermediately-adsorbing compound(s), providing a single-stage adsorptive separation of a compound having intermediate affinity to the adsorbent. The portion of the fluid flow rich in intermediately-adsorbing compound(s) may be established directly upstream from the point of fluid mixture feed injection into the fluid flow.

The present invention relates to a process for the preparation of a compound of formula I (I), comprising reacting a compound of formula II (II), with a brominating agent in the presence of an acidic catalyst to a compound of formula III (III), and reacting the compound of formula III in tetrahydrofuran or 2-methyl-tetrahydrofuran with potassium tert-butoxide to a compound of formula I.

##STR00001##

The present invention relates to a process for the preparation of a compound of formula I (I), comprising reacting a compound of formula II (II), with a brominating agent in the presence of an acidic catalyst to a compound of formula III (III), and reacting the compound of formula III in tetrahydrofuran or 2-methyl-tetrahydrofuran with potassium tert-butoxide to a compound of formula I.

##STR00001##

The invention generally relates to methods of making substituted arenes via direct C—H, C—O, C—S, or C—N bond conversion and methods of synthesizing isotopically-labeled substituted arenes via direct carbon-halogen bond conversion. The invention also relates to anaerobic catalyst systems comprising an acridinium photocatalyst and a nucleophile selected from a halide, a cyanide, and an isotopically-labeled amine. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The invention generally relates to methods of making substituted arenes via direct C—H, C—O, C—S, or C—N bond conversion and methods of synthesizing isotopically-labeled substituted arenes via direct carbon-halogen bond conversion. The invention also relates to anaerobic catalyst systems comprising an acridinium photocatalyst and a nucleophile selected from a halide, a cyanide, and an isotopically-labeled amine. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.