The disclosure provides processes for synthesizing compounds for use as CFTR modulators. ##STR00001##

The disclosure provides processes for synthesizing compounds for use as CFTR modulators. ##STR00001##

The present invention relates to a method for preparing an apparatus (or a plant comprising a plurality of apparatuses), for example a heat exchanger, a vaporizer or a distillation column, for use in a process (in particular a continuously operated process) for concentrating a mineral acid by evaporation of water, wherein the apparatus or the plant comprises (at least) a device which is resistant to the mineral acid and the device is flushed with an aqueous alkali metal hydroxide solution having a concentration by mass of alkali metal hydroxide in the range from 1% to 30% at a temperature in the range from 40° C. to 90° C. for a time of from 2 hours to 7 days.

The present invention relates to a method for preparing an apparatus (or a plant comprising a plurality of apparatuses), for example a heat exchanger, a vaporizer or a distillation column, for use in a process (in particular a continuously operated process) for concentrating a mineral acid by evaporation of water, wherein the apparatus or the plant comprises (at least) a device which is resistant to the mineral acid and the device is flushed with an aqueous alkali metal hydroxide solution having a concentration by mass of alkali metal hydroxide in the range from 1% to 30% at a temperature in the range from 40° C. to 90° C. for a time of from 2 hours to 7 days.

Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.

Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.

Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

The present invention relates to a process for the preparation of α-methyl-[4-(nitro)-2-(trifluoromethyl)]-benzyl nitrate and to the α-methyl-[4-(nitro)-2-(trifluoromethyl)]-benzyl nitrate.