C07C205/03

REVERSIBLY PROTECTED THIOLATED ELECTROPHILIC FATTY ACIDS AS PRODRUGS

Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.

REVERSIBLY PROTECTED THIOLATED ELECTROPHILIC FATTY ACIDS AS PRODRUGS

Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.

REVERSIBLY PROTECTED THIOLATED ELECTROPHILIC FATTY ACIDS AS PRODRUGS

Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.

Reversibly protected thiolated electrophilic fatty acids as prodrugs

Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.

Preparation of cyclic allylic nitro compounds

Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of -dehydroherbac and the scope is demonstrated with a small collection of additional substrates.

Preparation of cyclic allylic nitro compounds

Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of -dehydroherbac and the scope is demonstrated with a small collection of additional substrates.

Preparation of cyclic allylic nitro compounds

Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of -dehydroherbac and the scope is demonstrated with a small collection of additional substrates.

PREPARATION OF CYCLIC ALLYLIC NITRO COMPOUNDS

Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of -dehydroherbac and the scope is demonstrated with a small collection of additional substrates.

PREPARATION OF CYCLIC ALLYLIC NITRO COMPOUNDS

Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of -dehydroherbac and the scope is demonstrated with a small collection of additional substrates.

PREPARATION OF CYCLIC ALLYLIC NITRO COMPOUNDS

Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of -dehydroherbac and the scope is demonstrated with a small collection of additional substrates.