Patent classifications
C
CHEMISTRY; METALLURGY
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C07
ORGANIC CHEMISTRY
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C07C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
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205/00
Compounds containing nitro groups bound to a carbon skeleton
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C07C205/49
the carbon skeleton being further substituted by carboxyl groups
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C07C205/57
having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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C07C205/61
the carbon skeleton being further substituted by doubly-bound oxygen atoms
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C07C205/61

IRE-1α inhibitors
09546149 · 2017-01-17 · ·

Compounds which directly inhibit IRE-1 activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.