In a method for synthesizing 1,1-diamino-2,2-dinitroethylene (FOX-7) or an N-substituted diamino derivative thereof or a salt of 1,1-diamino-2,2-dinitroethylene or of the N-substituted diamino derivative, a carbodiimide is reacted with a dinitromethane anion. The reaction of the carbodiimide with the dinitromethane anion takes place in a solution.

In a method for synthesizing 1,1-diamino-2,2-dinitroethylene (FOX-7) or an N-substituted diamino derivative thereof or a salt of 1,1-diamino-2,2-dinitroethylene or of the N-substituted diamino derivative, a carbodiimide is reacted with a dinitromethane anion. The reaction of the carbodiimide with the dinitromethane anion takes place in a solution.

The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thi-azol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).

The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thi-azol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).

Described herein are catalytic hydrogenation and the use of ruthenium complexes having a bidentate diphosphine ligand or two monodentate phosphine ligands, two carboxylate ligands, and optionally a diamine ligand in hydrogenation processes for the reduction of imines into the corresponding amines.

Described herein are catalytic hydrogenation and the use of ruthenium complexes having a bidentate diphosphine ligand or two monodentate phosphine ligands, two carboxylate ligands, and optionally a diamine ligand in hydrogenation processes for the reduction of imines into the corresponding amines.

Described herein are catalytic hydrogenation and the use of ruthenium complexes having a bidentate diphosphine ligand or two monodentate phosphine ligands, two carboxylate ligands, and optionally a diamine ligand in hydrogenation processes for the reduction of imines into the corresponding amines.

The present invention relates to catalytically active material, comprising grains of non-graphitizing carbon with nickel nanoparticles dispersed therein, wherein dp, the average diameter of nickel nanoparticles in the non-graphitizing carbon grains, is in the range of 1 nm to 20 nm, D, the average distance between nickel nanoparticles in the non-graphitizing carbon grains, is in the range of 2 nm to 150 nm, and ω, the combined total mass fraction of metal in the non-graphitizing carbon grains, is in the range of 30 wt % to 70 wt % of the total mass of the non-graphitizing carbon grains, and wherein dp, D and ω conform to the following relation: 4.5 dp/ω>D≥0.25 dp/ω. The present invention, further, relates to a process for the manufacture of material according to the invention, as well as its use as a catalyst.

The present invention relates to catalytically active material, comprising grains of non-graphitizing carbon with nickel nanoparticles dispersed therein, wherein dp, the average diameter of nickel nanoparticles in the non-graphitizing carbon grains, is in the range of 1 nm to 20 nm, D, the average distance between nickel nanoparticles in the non-graphitizing carbon grains, is in the range of 2 nm to 150 nm, and ω, the combined total mass fraction of metal in the non-graphitizing carbon grains, is in the range of 30 wt % to 70 wt % of the total mass of the non-graphitizing carbon grains, and wherein dp, D and ω conform to the following relation: 4.5 dp/ω>D≥0.25 dp/ω. The present invention, further, relates to a process for the manufacture of material according to the invention, as well as its use as a catalyst.

The present invention relates to catalytically active material, comprising grains of non-graphitizing carbon with iron nanoparticles dispersed therein, wherein d.sub.p, the average diameter of iron nanoparticles in the non-graphitizing carbon grains, is in the range of 1 nm to 20 nm, D, the average distance between iron nanoparticles in the non-graphitizing carbon grains, is in the range of 2 nm to 150 nm, and ω, the combined total mass fraction of metal in the non-graphitizing carbon grains, is in the range of 30 wt % to 70 wt % of the total mass of the non-graphitizing carbon grains, and wherein d.sub.p, D and ω conform to the following relation: 4.5 d.sub.p/ω>D≥0.25 d.sub.p/ω. The present invention, further, relates to a process for the manufacture of material according to the invention, as well as its use as a catalyst.