The present invention relates to a process for synthesizing large scale a compound of formula (I), or pharmacuetically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

##STR00001##

The present invention relates to a process for synthesizing large scale a compound of formula (I), or pharmacuetically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

##STR00001##

The present invention relates to a process for synthesizing large scale a compound of formula (I), or pharmacuetically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

##STR00001##

There is disclosed a process for recovering monoethanolamine from an aqueous mother liquor solution comprising the steps of: (a) adding excess ammonia or alkali hydroxide and a solvent to the aqueous solution comprised of monoethanolamine sulfate and at least one component selected from the group of inorganic salts consisting of ammonium sulfate, ammonium sulfite, alkali sulfite, and alkali sulfate, to precipitate the inorganic salts, wherein the alkali is lithium, sodium, or potassium; (b) separating the inorganic salts by means of a solid-liquid separation to yield an aqueous solution comprised of the monoethanolamine; and (c) distilling the solvent to yield an aqueous solution comprised of the monoethanolamine and optionally purifying the MEA by distillation. The recovered MEA is recycled to produce taurine.

There is disclosed a process for recovering monoethanolamine from an aqueous mother liquor solution comprising the steps of: (a) adding excess ammonia or alkali hydroxide and a solvent to the aqueous solution comprised of monoethanolamine sulfate and at least one component selected from the group of inorganic salts consisting of ammonium sulfate, ammonium sulfite, alkali sulfite, and alkali sulfate, to precipitate the inorganic salts, wherein the alkali is lithium, sodium, or potassium; (b) separating the inorganic salts by means of a solid-liquid separation to yield an aqueous solution comprised of the monoethanolamine; and (c) distilling the solvent to yield an aqueous solution comprised of the monoethanolamine and optionally purifying the MEA by distillation. The recovered MEA is recycled to produce taurine.

The present disclosure relates to methods for the production of the isomerically pure or isomerically enriched cis-clomiphene and salts thereof.

The present disclosure relates to methods for the production of the isomerically pure or isomerically enriched cis-clomiphene and salts thereof.

The present disclosure relates to methods for the production of the isomerically pure or isomerically enriched cis-clomiphene and salts thereof.

Organic ligands and methods for preparing a variety of organic ligands are provided. The subject methods provide for the preparation of organic ligands in high yield and purity for use as ligands for attachment to nanoparticles to enable the formation of three dimensional nanocapsules of stably associated organic ligand-functionalized nanoparticles. Compositions that include these nanocapsules, as well as methods of making the nanocapsules are also provided.

Organic ligands and methods for preparing a variety of organic ligands are provided. The subject methods provide for the preparation of organic ligands in high yield and purity for use as ligands for attachment to nanoparticles to enable the formation of three dimensional nanocapsules of stably associated organic ligand-functionalized nanoparticles. Compositions that include these nanocapsules, as well as methods of making the nanocapsules are also provided.