The present invention relates to the use of mono- and bis nitrosylated propanediols, and compositions and formulations comprising the same, in methods for the treatment of a microbial infection.

The present invention relates to the use of mono- and bis nitrosylated propanediols, and compositions and formulations comprising the same, in methods for the treatment of a microbial infection.

Disclosed is an organic amine salt foaming agent, that is, a composite polyurethane foaming agent, comprising: 1) hexafluorobutene; and 2) an alkanolamine salt mixture (MAA), the alkanolamine salt mixture (MAA) contains an organic amine salt compound having the following general formula (I): A.sup.n−[B.sup.m+].sub.p (I); wherein A.sup.n− is one or two or three selected from the following anions: (b) carbonate: CO.sub.3.sup.2−; (c) formate: HCOO.sup.−; (d) bicarbonate: HO—COO.sup.−. A polyurethane foaming method using carbon dioxide and an organic amine in combination is also disclosed, in which carbon dioxide is added to a polyurethane composition for foaming. A method for preparing an alkanolamine carbonate salt with low water content from ammonium carbonate and an epoxide is additionally disclosed, in which a liquid alkanolamine salt mixture is used as a dispersion medium or as a solvent for reaction raw material.

A method for purification of organic amines, comprising introducing a resin polymer matrix to a liquid containing at least an organic amine bonded to at least one metallic element, wherein the resin polymer matrix is embedded with an amino compound selected from the group consisting of iminodiacetic acid, aminomethylphosphonic acid or a combination thereof, and wherein the embedded resin polymer matrix binds the at least one metallic element, and the at least one metallic element is removed from the organic amine.

A method for purification of organic amines, comprising introducing a resin polymer matrix to a liquid containing at least an organic amine bonded to at least one metallic element, wherein the resin polymer matrix is embedded with an amino compound selected from the group consisting of iminodiacetic acid, aminomethylphosphonic acid or a combination thereof, and wherein the embedded resin polymer matrix binds the at least one metallic element, and the at least one metallic element is removed from the organic amine.

The invention relates to an organic ammonium salt of formula (I), wherein the symbols have the following meanings: A- is an anionic pesticide, R.sup.1 is H, C.sub.1C.sub.4-alkyl, CH.sub.2CH.sub.2OH or CH.sub.2CH(CH.sub.3)OH; R is H, CH.sub.3 or two adjacent radicals R together form a group —C(R′)— and R′ is equal to or different from H or CH.sub.3, wherein said salt is suitable for reducing the volatility of active substances in the spray application of anionic pesticides.

##STR00001##

The invention relates to an organic ammonium salt of formula (I), wherein the symbols have the following meanings: A- is an anionic pesticide, R.sup.1 is H, C.sub.1C.sub.4-alkyl, CH.sub.2CH.sub.2OH or CH.sub.2CH(CH.sub.3)OH; R is H, CH.sub.3 or two adjacent radicals R together form a group —C(R′)— and R′ is equal to or different from H or CH.sub.3, wherein said salt is suitable for reducing the volatility of active substances in the spray application of anionic pesticides.

##STR00001##

The invention relates to the field of pharmaceutical synthesis, in particular to the preparation method of hexahydrofuro-furanol derivative, intermediates thereof and preparation methods thereof. The preparation methods comprises the steps of halogenation reaction, acylation reaction, enzymatic reduction reaction, reaction with amine compounds, reduction ring closure reaction (A1, A2, B, Cp1, C.sub.L, Cf)

##STR00001##

wherein, R.sub.1, R.sub.2, R.sub.3 are hydrogen or hydroxy protecting groups; R.sub.4 and R.sub.5 are the same or different and are phenyl, alkyl or substituted phenyl. In the preparation process of hexahydrofuro-furanol derivatives, the chirality is constructed by enzymatic method, and the product can be prepared with very high optical purity by adopting such technical means. The preparation method can be used to prepare the key intermediate, (3R, 3aS, 6aR)-hexahydrofuro[2,3-b]-3-ol, of Darunavir, in commercial production, which is a very economical route suitable for industrial production.

Disclosed is an organic amine salt foaming agent, that is, a composite polyurethane foaming agent, comprising: 1) hexafluorobutene; and 2) an alkanolamine salt mixture (MAA), the alkanolamine salt mixture (MAA) contains an organic amine salt compound having the following general formula (I): A.sup.n[B.sup.m+].sub.p (I); wherein A.sup.n is one or two or three selected from the following anions: (b) carbonate: CO.sub.3.sup.2; (c) formate: HCOO.sup.; (d) bicarbonate: HOCOO.sup.. A polyurethane foaming method using carbon dioxide and an organic amine in combination is also disclosed, in which carbon dioxide is added to a polyurethane composition for foaming. A method for preparing an alkanolamine carbonate salt with low water content from ammonium carbonate and an epoxide is additionally disclosed, in which a liquid alkanolamine salt mixture is used as a dispersion medium or as a solvent for reaction raw material.

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's extend the buffering range resulting in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.