Provided are methods to destabilize emulsion feedstocks. In the methods, a moderate temperature is applied to the feedstock to create a first mixture. The moderate temperature may be between 120 and 220 degrees Celsius. The first mixture is mixed at the moderate temperature, such as by staged mixing in some embodiments. Moreover, the first mixture is retained at the moderate temperature for up to six hours. The first mixture is separated into an oil phase, convoluted phase, and a water phase. In some embodiments, the moderate temperature may be 125 to 150 degrees Celsius, such as between 125 and 130 degrees Celsius. Moreover, the first mixture may be retained at the moderate temperature for between forty-five minutes and four hours, such as from two to four hours. The separation may occur at the moderate temperature.

Provided are methods to destabilize emulsion feedstocks. In the methods, a moderate temperature is applied to the feedstock to create a first mixture. The moderate temperature may be between 120 and 220 degrees Celsius. The first mixture is mixed at the moderate temperature, such as by staged mixing in some embodiments. Moreover, the first mixture is retained at the moderate temperature for up to six hours. The first mixture is separated into an oil phase, convoluted phase, and a water phase. In some embodiments, the moderate temperature may be 125 to 150 degrees Celsius, such as between 125 and 130 degrees Celsius. Moreover, the first mixture may be retained at the moderate temperature for between forty-five minutes and four hours, such as from two to four hours. The separation may occur at the moderate temperature.

The application relates to a process for drying a composition comprising an alkali metal salt of a compound of general formula (I) R.sup.1R.sup.2N—CHR.sup.3—COOM or formula (II) R.sup.1R.sup.2N—CHR.sup.3CHR.sup.3—COOM, in particular N,N-dimethyl glycinate salt, and the use thereof. In the process, the composition, in particular the N,N-di methyl glycinate salt, is dried by feeding the composition into a fluidized bed dryer and subjecting the composition to a heat treatment by contacting the composition in the fluidized bed dryer with a drying gas stream, and during the heat treatment a solution or dispersion of the composition is sprayed onto at least a portion of the composition present in the fluidized bed dryer, or alternatively or in addition the composition, in particular N,N-dimethyl glycinate salt, is fed into a fluidized bed dryer and subjected to heat treatment in the fluidized bed dryer by contacting the composition with a drying gas stream, and the temperature of the composition in the fluidized bed during the heat treatment does not exceed 50° C.

The application relates to a process for drying a composition comprising an alkali metal salt of a compound of general formula (I) R.sup.1R.sup.2N—CHR.sup.3—COOM or formula (II) R.sup.1R.sup.2N—CHR.sup.3CHR.sup.3—COOM, in particular N,N-dimethyl glycinate salt, and the use thereof. In the process, the composition, in particular the N,N-di methyl glycinate salt, is dried by feeding the composition into a fluidized bed dryer and subjecting the composition to a heat treatment by contacting the composition in the fluidized bed dryer with a drying gas stream, and during the heat treatment a solution or dispersion of the composition is sprayed onto at least a portion of the composition present in the fluidized bed dryer, or alternatively or in addition the composition, in particular N,N-dimethyl glycinate salt, is fed into a fluidized bed dryer and subjected to heat treatment in the fluidized bed dryer by contacting the composition with a drying gas stream, and the temperature of the composition in the fluidized bed during the heat treatment does not exceed 50° C.

The application relates to a process for drying a composition comprising an alkali metal salt of a compound of general formula (I) R.sup.1R.sup.2N—CHR.sup.3—COOM or formula (II) R.sup.1R.sup.2N—CHR.sup.3CHR.sup.3—COOM, in particular N,N-dimethyl glycinate salt, and the use thereof. In the process, the composition, in particular the N,N-di methyl glycinate salt, is dried by feeding the composition into a fluidized bed dryer and subjecting the composition to a heat treatment by contacting the composition in the fluidized bed dryer with a drying gas stream, and during the heat treatment a solution or dispersion of the composition is sprayed onto at least a portion of the composition present in the fluidized bed dryer, or alternatively or in addition the composition, in particular N,N-dimethyl glycinate salt, is fed into a fluidized bed dryer and subjected to heat treatment in the fluidized bed dryer by contacting the composition with a drying gas stream, and the temperature of the composition in the fluidized bed during the heat treatment does not exceed 50° C.

This application relates to pharmaceutical engineering, and more particularly to a continuous-flow preparation method of diclofenac sodium. The continuous-flow preparation method includes: subjecting aniline and chloroacetic acid to amidation to obtain 2-chloro-N-phenylacetamide (3); subjecting 2-chloro-N-phenylacetamide (3) and 2,6-dichlorophenol to continuous condensation to obtain N-(2,6-dichlorophenyl)-2-hydroxy-N-phenylacetamide (5); subjecting N-(2,6-dichlorophenyl)-2-hydroxy-N-phenylacetamide (5) and thionyl chloride to chlorination to obtain N-(2,6-dichlorophenyl)-2-chloro-N-phenylacetamide (6); subjecting N-(2,6-dichlorophenyl)-2-chloro-N-phenylacetamide (6) to Friedel-Crafts alkylation in the presence of aluminum chloride to obtain 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indo1-2-one (7); and subjecting 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one (7) to hydrolysis to obtain the diclofenac sodium.

This application relates to pharmaceutical engineering, and more particularly to a continuous-flow preparation method of diclofenac sodium. The continuous-flow preparation method includes: subjecting aniline and chloroacetic acid to amidation to obtain 2-chloro-N-phenylacetamide (3); subjecting 2-chloro-N-phenylacetamide (3) and 2,6-dichlorophenol to continuous condensation to obtain N-(2,6-dichlorophenyl)-2-hydroxy-N-phenylacetamide (5); subjecting N-(2,6-dichlorophenyl)-2-hydroxy-N-phenylacetamide (5) and thionyl chloride to chlorination to obtain N-(2,6-dichlorophenyl)-2-chloro-N-phenylacetamide (6); subjecting N-(2,6-dichlorophenyl)-2-chloro-N-phenylacetamide (6) to Friedel-Crafts alkylation in the presence of aluminum chloride to obtain 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indo1-2-one (7); and subjecting 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one (7) to hydrolysis to obtain the diclofenac sodium.

This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further down-stream purification.

This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further down-stream purification.

This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further down-stream purification.