Process for making a powder or granule containing at least one chelating agent selected from alkali metal salts of methyl glycine diacetic acid (MGDA) and glutamic acid diacetate (GLDA) and iminodisuccinic acid (IDS), said process comprising the steps of (a) introducing an aqueous solution or aqueous slurry of the respective chelating agent (A) into a spray-dryer or spray-granulator, and removing most of said water by spray-drying or spray granulation using a gas with an inlet temperature of 125 to 250° C., (b) withdrawingpowder or granules, respectively, from the spray-dryer or spray-granulator, respectively, (c) separating off fines from said powder or granules, wherein said fines have a maximum particle diameter of 350 μm, (d) separating off lumps from said powder or granules, wherein said lumps have a particle diameter of 1,500 μm or more, (e) milling said lumps to a maximum particle diameter of 500 μm, (f) re-introducing said fines from step (c) and milled lumps from step (e) into the spray-dryer or spray-granulator, wherein the share of fines is in the range of from 0.5 to 20% by weight of the total chelating agent (A) withdrawn in step (b) and the share of milled lumps is in the range of from 5 to 60% by weight of the total chelating agent (A) withdrawn in step (b).

Process for making a powder or granule containing at least one chelating agent selected from alkali metal salts of methyl glycine diacetic acid (MGDA) and glutamic acid diacetate (GLDA) and iminodisuccinic acid (IDS), said process comprising the steps of (a) introducing an aqueous solution or aqueous slurry of the respective chelating agent (A) into a spray-dryer or spray-granulator, and removing most of said water by spray-drying or spray granulation using a gas with an inlet temperature of 125 to 250° C., (b) withdrawingpowder or granules, respectively, from the spray-dryer or spray-granulator, respectively, (c) separating off fines from said powder or granules, wherein said fines have a maximum particle diameter of 350 μm, (d) separating off lumps from said powder or granules, wherein said lumps have a particle diameter of 1,500 μm or more, (e) milling said lumps to a maximum particle diameter of 500 μm, (f) re-introducing said fines from step (c) and milled lumps from step (e) into the spray-dryer or spray-granulator, wherein the share of fines is in the range of from 0.5 to 20% by weight of the total chelating agent (A) withdrawn in step (b) and the share of milled lumps is in the range of from 5 to 60% by weight of the total chelating agent (A) withdrawn in step (b).

Process for making a powder or granule containing at least one chelating agent selected from alkali metal salts of methyl glycine diacetic acid (MGDA) and glutamic acid diacetate (GLDA) and iminodisuccinic acid (IDS), said process comprising the steps of (a) introducing an aqueous solution or aqueous slurry of the respective chelating agent (A) into a spray-dryer or spray-granulator, and removing most of said water by spray-drying or spray granulation using a gas with an inlet temperature of 125 to 250° C., (b) withdrawingpowder or granules, respectively, from the spray-dryer or spray-granulator, respectively, (c) separating off fines from said powder or granules, wherein said fines have a maximum particle diameter of 350 μm, (d) separating off lumps from said powder or granules, wherein said lumps have a particle diameter of 1,500 μm or more, (e) milling said lumps to a maximum particle diameter of 500 μm, (f) re-introducing said fines from step (c) and milled lumps from step (e) into the spray-dryer or spray-granulator, wherein the share of fines is in the range of from 0.5 to 20% by weight of the total chelating agent (A) withdrawn in step (b) and the share of milled lumps is in the range of from 5 to 60% by weight of the total chelating agent (A) withdrawn in step (b).

Method of purifying an alkali metal salt of a compound of the general Formula (I) or Formula (II)

##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are independently H, an alkyl, an alkenyl, or a hydroxyalkyl radical containing from 1 to 18 carbon atoms, or from 1 to 6 carbon atoms; or wherein R.sup.1 and R.sup.2 form jointly together with the N atom a heterocyclic 5- or 6-membered ring; said method comprising providing a mixture comprising said, an alkali metal hydroxide and water, and subjecting the mixture to a step (X): (X) reducing the quantity of removing said alkali metal hydroxide from the mixture; wherein (A) said alkali metal hydroxide is reduced by subjecting said mixture to electrodialysis; and/or (B) said alkali metal hydroxide is reduced by adding an acid to said mixture.

Method of purifying an alkali metal salt of a compound of the general Formula (I) or Formula (II)

##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are independently H, an alkyl, an alkenyl, or a hydroxyalkyl radical containing from 1 to 18 carbon atoms, or from 1 to 6 carbon atoms; or wherein R.sup.1 and R.sup.2 form jointly together with the N atom a heterocyclic 5- or 6-membered ring; said method comprising providing a mixture comprising said, an alkali metal hydroxide and water, and subjecting the mixture to a step (X): (X) reducing the quantity of removing said alkali metal hydroxide from the mixture; wherein (A) said alkali metal hydroxide is reduced by subjecting said mixture to electrodialysis; and/or (B) said alkali metal hydroxide is reduced by adding an acid to said mixture.

A method for separating one or more amino acids from a whole stillage byproduct produced in a corn dry milling process for making alcohol and system therefore is disclosed. In one embodiment, the method includes separating the whole stillage byproduct into an insoluble solids portion and a thin stillage portion, which include protein and amino acids. Thereafter, the thin stillage portion can be separated into a water soluble solids portion and a protein and amino acids portion. The resulting protein and amino acids portion can be separated into an amino acid(s) portion and a protein portion, both of which may be optionally dried, utilizing microfiltration, ultrafiltration, electrophoresis techniques/devices, or combinations thereof. The amino acid(s) in the resulting amino acid(s) portion may be further processed to be sold and/or used as or in, for example, nutritional supplements, flavor enhancers, animal feed additives, pharmaceuticals, industrial usage, fertilizers, herbicides, or as a feed source for other processing systems.

A method for separating one or more amino acids from a whole stillage byproduct produced in a corn dry milling process for making alcohol and system therefore is disclosed. In one embodiment, the method includes separating the whole stillage byproduct into an insoluble solids portion and a thin stillage portion, which include protein and amino acids. Thereafter, the thin stillage portion can be separated into a water soluble solids portion and a protein and amino acids portion. The resulting protein and amino acids portion can be separated into an amino acid(s) portion and a protein portion, both of which may be optionally dried, utilizing microfiltration, ultrafiltration, electrophoresis techniques/devices, or combinations thereof. The amino acid(s) in the resulting amino acid(s) portion may be further processed to be sold and/or used as or in, for example, nutritional supplements, flavor enhancers, animal feed additives, pharmaceuticals, industrial usage, fertilizers, herbicides, or as a feed source for other processing systems.

The present disclosure discloses a method for synthesizing quinolones intermediates by a continuous flow reaction. Specifically, according to the method, a microchannel reactor is used, which improves the selectivity and conversion rate of the reaction, and the conversion rate of compound ii is increased to more than 95% and the yield is increased to more than 85%; avoids the use of a solvent such as methanol, and methyl tert-butyl ether, etc., in the intermittent reaction process, which simplifies the post-processing method, shortens the overall operation time from about 24 hours to a few minutes, greatly improving the production efficiency, and realizing the continuity and automation of the whole process; and thus makes the product have high purity and high yield, which is suitable for industrial production.

The present disclosure discloses a method for synthesizing quinolones intermediates by a continuous flow reaction. Specifically, according to the method, a microchannel reactor is used, which improves the selectivity and conversion rate of the reaction, and the conversion rate of compound ii is increased to more than 95% and the yield is increased to more than 85%; avoids the use of a solvent such as methanol, and methyl tert-butyl ether, etc., in the intermittent reaction process, which simplifies the post-processing method, shortens the overall operation time from about 24 hours to a few minutes, greatly improving the production efficiency, and realizing the continuity and automation of the whole process; and thus makes the product have high purity and high yield, which is suitable for industrial production.

Process for making a powder or granule containing at least one chelating agent selected from alkali metal salts of methyl glycine diacetic acid (MGDA) and glutamic acid diacetate (GLDA) and iminodisuccinic acid (IDS), said process comprising the steps of (a) introducing an aqueous solution or aqueous slurry of the respective chelating agent (A) into a spray-dryer or spray-granulator, and removing most of said water by spray-drying or spray granulation using a gas with an inlet temperature of 125 to 250 C., (b) withdrawing powder or granules, respectively, from the spray-dryer or spray-granulator, respectively, (c) separating off fmes from said powder or granules, wherein said fmes have a maximum particle diameter of 350 (d) separating off lumps from said powder or granules, wherein said lumps have a particle diameter of 1,500 m or more, (e) milling said lumps to a maximum particle diameter of 500 m, (f) re-introducing said fmes from step (c) and milled lumps from step (e) into the spray-dryer or spray-granulator, wherein the share of fines is in the range of from 0.5 to 20% by weight of the total chelating agent (A) withdrawn in step (b) and the share of milled lumps is in the range of from 5 to 60% by weight of the total chelating agent (A) withdrawn in step (b).