The present application is related to an improved process for synthesising 1-(difluoromethyl)-3-iodobicyclo[1.1.1]pentane from difluoromethyl iodide and [1.1.1]propellane. Difluoromethyl iodide is made by reacting an iodide salt with chlorodifluoroacetic acid in the presence of a solvent such as sulfolane and an inorganic base, [1.1.1]propellane is synthesised by reacting 1,1-dibromo-2,2-cis(chloromethyl)cyclopropane with a reagent such as magnesium, methyllithium or phenyllithium.

The present application is related to an improved process for synthesising 1-(difluoromethyl)-3-iodobicyclo[1.1.1]pentane from difluoromethyl iodide and [1.1.1]propellane. Difluoromethyl iodide is made by reacting an iodide salt with chlorodifluoroacetic acid in the presence of a solvent such as sulfolane and an inorganic base, [1.1.1]propellane is synthesised by reacting 1,1-dibromo-2,2-cis(chloromethyl)cyclopropane with a reagent such as magnesium, methyllithium or phenyllithium.

Provided are a method for producing N-(-alkoxyethyl)formamide, comprising adding an acid catalyst to the mixed liquid within 3 hours from start of mixing after mixing of N-(-hydroxyethyl)formamide with an alcohol has been started, by which the N-(-alkoxyethyl)formamide can be produced at a high yield without additional investment in plant and equipment while suppressing an increase in the temperature of the mixed liquid and preventing corrosion of a pipe; and a method for producing N-(-alkoxyethyl)formamide, comprising degassing carbon dioxide in the reaction of N-(-hydroxyethyl)formamide with an alcohol, by which the N-(-alkoxyethyl)formamide having a decreased carbonate concentration can be produced.

Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX transition metal compound.

Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX transition metal compound.

Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX transition metal compound.