The present invention relates to a process for obtaining amidated fatty acids or derivatives thereof good in color even after longer storage with low concentrations of undesired by-products. The present invention also relates to use of amidated fatty acids or derivatives thereof obtained by the process in the cosmetic applications. Further, the present invention also relates to use of amidated fatty acids or derivatives thereof obtained by the process in the industrial applications.

The present invention relates to a process for obtaining amidated fatty acids or derivatives thereof good in color even after longer storage with low concentrations of undesired by-products. The present invention also relates to use of amidated fatty acids or derivatives thereof obtained by the process in the cosmetic applications. Further, the present invention also relates to use of amidated fatty acids or derivatives thereof obtained by the process in the industrial applications.

A method for producing N-vinylacetamide includes a feeding step of feeding a raw material containing N-(1-methoxyethyl)acetamide (MEA) to an evaporator, an evaporation step of evaporating, by the evaporator, the raw material, to form a vaporized raw material, a superheating step of feeding the vaporized raw material to a superheater, and superheating the vaporized raw material such that a superheating temperature of the vaporized raw material is equal to or more than a temperature higher by 5° C. than a boiling point of the N-(1-methoxyethyl)acetamide (MEA) under an inner pressure of the superheater and equal to or less than 200° C., and a thermal decomposition step of feeding the superheated vaporized raw material to a thermal decomposition reactor, to thermally decompose the superheated vaporized raw material, and a content of the N-(1-methoxyethyl)acetamide in the raw material is from 80 to 100 mass %.

A method for producing N-vinylacetamide includes a feeding step of feeding a raw material containing N-(1-methoxyethyl)acetamide (MEA) to an evaporator, an evaporation step of evaporating, by the evaporator, the raw material, to form a vaporized raw material, a superheating step of feeding the vaporized raw material to a superheater, and superheating the vaporized raw material such that a superheating temperature of the vaporized raw material is equal to or more than a temperature higher by 5° C. than a boiling point of the N-(1-methoxyethyl)acetamide (MEA) under an inner pressure of the superheater and equal to or less than 200° C., and a thermal decomposition step of feeding the superheated vaporized raw material to a thermal decomposition reactor, to thermally decompose the superheated vaporized raw material, and a content of the N-(1-methoxyethyl)acetamide in the raw material is from 80 to 100 mass %.

Aspects of the disclosure includes methods for preparing an amorphous solid composition of a fatty acid metal salt. In practicing the subject methods according to certain embodiments, a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane organic salt is contacted with a metal base to produce a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt; and the succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt is precipitated in a solvent to produce an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt composition. An amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt is also provided.

Aspects of the disclosure includes methods for preparing an amorphous solid composition of a fatty acid metal salt. In practicing the subject methods according to certain embodiments, a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane organic salt is contacted with a metal base to produce a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt; and the succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt is precipitated in a solvent to produce an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt composition. An amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt is also provided.

Aspects of the disclosure includes methods for preparing an amorphous solid composition of a fatty acid metal salt. In practicing the subject methods according to certain embodiments, a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane organic salt is contacted with a metal base to produce a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt; and the succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt is precipitated in a solvent to produce an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt composition. An amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt is also provided.

Aspects of the disclosure includes methods for preparing an amorphous solid composition of a fatty acid metal salt. In practicing the subject methods according to certain embodiments, a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane organic salt is contacted with a metal base to produce a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt; and the succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt is precipitated in a solvent to produce an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt composition. An amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt is also provided.

A continuous paracetamol preparation method, including a nitration step or a nitrosation step to obtain p-nitrophenol or p-nitrosophenol respectively. P-nitrophenol or p-nitrosophenol can then be converted into paracetamol by hydrogenation, followed by acylation. This continuous paracetamol preparation method makes it possible to obtain paracetamol with a very good regioselectivity and excellent yields.

A continuous paracetamol preparation method, including a nitration step or a nitrosation step to obtain p-nitrophenol or p-nitrosophenol respectively. P-nitrophenol or p-nitrosophenol can then be converted into paracetamol by hydrogenation, followed by acylation. This continuous paracetamol preparation method makes it possible to obtain paracetamol with a very good regioselectivity and excellent yields.