New photoresist compositions are provided that comprise a component that comprises an amide group and multiple hydroxyl groups. Preferred photoresists of the invention may comprise a resin with photoacid-labile groups; a photoacid generator compound; and an amide component with multiple hydroxyl groups that can function to decrease undesired photogenerated-acid diffusion out of unexposed regions of a photoresist coating layer.

New photoresist compositions are provided that comprise a component that comprises an amide group and multiple hydroxyl groups. Preferred photoresists of the invention may comprise a resin with photoacid-labile groups; a photoacid generator compound; and an amide component with multiple hydroxyl groups that can function to decrease undesired photogenerated-acid diffusion out of unexposed regions of a photoresist coating layer.

The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, cancer.

The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, cancer.

The present invention relates to compounds of formula (I): ##STR00001## including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, cancer.

The present invention relates to compounds of formula (I):

##STR00001##

including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, cancer.

A method for assessing a state of a living cell using surface enhanced Raman spectroscopy (SERS) is provided. The method m ay include modifying one or more living eel Is with an alkyne-containing compound to form one or more modified living cells, mixing the one or more modified living cells with a SERS-active material to form a mixture, injecting the mixture into a conduitdefined by an innerwall of a hollow core photonic crystal fiber, and detecting a surface enhanced Raman signal from the mixture in the conduit. In preferred embodiments, the alkyne containing compound is linoleamide alkyne (LLA) for the detection of lipid peroxidation or 4-(dihydroxyborophenyl) acetylene (DBA) for the detection of sialic acid expression in cells, both using gold nanoparticles as the SERS-active material.

A method for assessing a state of a living cell using surface enhanced Raman spectroscopy (SERS) is provided. The method m ay include modifying one or more living eel Is with an alkyne-containing compound to form one or more modified living cells, mixing the one or more modified living cells with a SERS-active material to form a mixture, injecting the mixture into a conduitdefined by an innerwall of a hollow core photonic crystal fiber, and detecting a surface enhanced Raman signal from the mixture in the conduit. In preferred embodiments, the alkyne containing compound is linoleamide alkyne (LLA) for the detection of lipid peroxidation or 4-(dihydroxyborophenyl) acetylene (DBA) for the detection of sialic acid expression in cells, both using gold nanoparticles as the SERS-active material.

A process for preparing acylglycinates of the formula (I) wherein R.sup.1 is a linear or branched, saturated alkanoyl group having 6 to 30 carbon atoms, or is a linear or branched, singly or multiply unsaturated alkenoyl group having 6 to 30 carbon atoms, and Q.sup.+ is a cation, wherein glycine is reacted with fatty acid chloride R.sup.1Cl, in water and in the presence of a basic alkali metal compound which yields cations Q.sup.+, but in the absence of organic solvents, at 25 50 C. Also described are compositions comprising acylglycinates of the formula (I).

##STR00001##

A process for preparing acylglycinates of the formula (I) wherein R.sup.1 is a linear or branched, saturated alkanoyl group having 6 to 30 carbon atoms, or is a linear or branched, singly or multiply unsaturated alkenoyl group having 6 to 30 carbon atoms, and Q.sup.+ is a cation, wherein glycine is reacted with fatty acid chloride R.sup.1Cl, in water and in the presence of a basic alkali metal compound which yields cations Q.sup.+, but in the absence of organic solvents, at 25 50 C. Also described are compositions comprising acylglycinates of the formula (I).

##STR00001##