The present disclosure provides a continuous process for the synthesis coupled compounds of diazonium salts including azo dyes involving in-situ generation of diazonium salts. It further discloses a set up to carry out the process for the synthesis of coupled compounds of diazonium salts.

This invention concerns a versatile and simple one-pot method to prepare nanomaterials, and in particular nanoparticles, grafted with an ultra-thin layer of calixarenes by placing at 5 least one oxidized metal with at least one calix[n]arene diazonium salt in the presence of a reducing agent in a solvent, and heating the traction mixture to obtain a metal-based nanomaterial coated with calix[n]arenes. The invention further concerns the coupling of organic molecules or biomolecules to the calixarene-grafted nanomaterials in order to further functionalize the surface of the particles. The metal-based nanomaterial coated with 10 calix[n]arenes can for example be used in immunoassays.

The present invention relates to an improved process for the preparation of trifloxystrobin of formula (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and chemical purity. ##STR00001##

The present invention relates to an improved process for the preparation of trifloxystrobin of formula (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and chemical purity. ##STR00001##

Provided herein are improved processes for convening C7-amino-substituted tetracylines to C7-fluoro-substituted tetracyclines as well as intermediates produced by or used in these processes. In one embodiment, a thermal fluorination method is provided in which a suspension comprising a non-polar organic solvent and a C7-diazo-substituted tetracycline hexafluorophosphate, hexafluoarsenate or hexafluorosilicate salt, or a salt, solvate or combination thereof is healed to provide a C7-fluoro-substituted tetracyline, or salt, solvate or combination thereof. In another embodiment, a photolytic fluorination is provided in which a solution comprising an ionic liquid and a C-7diazo-substituted tetracyline tetrafluoroborate, hexafluorophosphate, hexafluoroarsenate or hexafluorosilicate salt, or a salt, solvate or combination thereof is irradiated to provide a C7-fluoro-substituted tetracyline, or salt, solvate or combination thereof.

Provided herein are improved processes for convening C7-amino-substituted tetracylines to C7-fluoro-substituted tetracyclines as well as intermediates produced by or used in these processes. In one embodiment, a thermal fluorination method is provided in which a suspension comprising a non-polar organic solvent and a C7-diazo-substituted tetracycline hexafluorophosphate, hexafluoarsenate or hexafluorosilicate salt, or a salt, solvate or combination thereof is healed to provide a C7-fluoro-substituted tetracyline, or salt, solvate or combination thereof. In another embodiment, a photolytic fluorination is provided in which a solution comprising an ionic liquid and a C-7diazo-substituted tetracyline tetrafluoroborate, hexafluorophosphate, hexafluoroarsenate or hexafluorosilicate salt, or a salt, solvate or combination thereof is irradiated to provide a C7-fluoro-substituted tetracyline, or salt, solvate or combination thereof.

A process for the preparation of 2-substituted-1,4-benzenediamines, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely the 2-substituted aniline.

A process for the preparation of 2-substituted-1,4-benzenediamines, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely the 2-substituted aniline.

The invention discloses a special-purpose reactive disperse dye for waterless dyeing of natural fibers in supercritical CO.sub.2 fluid and an intermediate thereof. The reactive disperse dye has a longer alkane-chain bridging group between a chromophoric parent structure and an active group of the dye, which effectively promotes the donating-withdrawing effect on the electron cloud in the conjugated system, enhances the hyperchromic effect, effectively reduce the influence of the active group itself and its reaction on the dye coloring system, improves the color and stability against acid and alkali of the dye, and facilitate the improvement of the compatibility of the dye with supercritical fluid and the dyeing performance for natural fibers as well. The invention also discloses an intermediate of the reactive disperse dye, and a method for preparing the reactive disperse dye.

The invention discloses a special-purpose reactive disperse dye for waterless dyeing of natural fibers in supercritical CO.sub.2 fluid and an intermediate thereof. The reactive disperse dye has a longer alkane-chain bridging group between a chromophoric parent structure and an active group of the dye, which effectively promotes the donating-withdrawing effect on the electron cloud in the conjugated system, enhances the hyperchromic effect, effectively reduce the influence of the active group itself and its reaction on the dye coloring system, improves the color and stability against acid and alkali of the dye, and facilitate the improvement of the compatibility of the dye with supercritical fluid and the dyeing performance for natural fibers as well. The invention also discloses an intermediate of the reactive disperse dye, and a method for preparing the reactive disperse dye.