4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.

4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.

Methods of making antidegradant compounds are disclosed in which a p-phenylenediamine is reacted with a dicarbonyl to thereby obtain a diimine, which is reduced to obtain mixtures comprising the antidegradant compound.

Methods of making antidegradant compounds are disclosed in which a p-phenylenediamine is reacted with a dicarbonyl to thereby obtain a diimine, which is reduced to obtain mixtures comprising the antidegradant compound.

Cleavable surfactants of formula (I) ##STR00001##
having a total hydrophilic-lipophilic balance (HLB) of between 3 and 18 and wherein A is a group capable of releasing a flavor or fragrance aldehyde of formula (R.sup.1)CHO or a flavor or fragrance ketone of formula (R.sup.1)(R.sup.2)CO and is of formula ##STR00002##
wherein the wavy line indicates the location of the bond between L and A; R.sup.1 and R.sup.2 represent a hydrogen atom or a saturated or unsaturated C.sub.1-C.sub.18 hydrocarbon group, provided that at least one of the R.sup.1 or R.sup.2 groups has 6 consecutive carbon atoms and that both R.sup.1 and R.sup.2 taken together comprise a maximum of 18 carbon atoms; and L is a linear, branched or cyclic, saturated or unsaturated C.sub.3 to C.sub.40 hydrocarbon group. These surfactants solubilize and/or stabilize flavor and fragrance aldehydes and ketones in an aqueous environment and at the same time to control their release by hydrolysis.

Cleavable surfactants of formula (I) ##STR00001##
having a total hydrophilic-lipophilic balance (HLB) of between 3 and 18 and wherein A is a group capable of releasing a flavor or fragrance aldehyde of formula (R.sup.1)CHO or a flavor or fragrance ketone of formula (R.sup.1)(R.sup.2)CO and is of formula ##STR00002##
wherein the wavy line indicates the location of the bond between L and A; R.sup.1 and R.sup.2 represent a hydrogen atom or a saturated or unsaturated C.sub.1-C.sub.18 hydrocarbon group, provided that at least one of the R.sup.1 or R.sup.2 groups has 6 consecutive carbon atoms and that both R.sup.1 and R.sup.2 taken together comprise a maximum of 18 carbon atoms; and L is a linear, branched or cyclic, saturated or unsaturated C.sub.3 to C.sub.40 hydrocarbon group. These surfactants solubilize and/or stabilize flavor and fragrance aldehydes and ketones in an aqueous environment and at the same time to control their release by hydrolysis.

Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.

Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.

Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.

Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.