A composition for detecting an acidic compound and a method using the same are discloses herein. In some embodiments, the method includes contacting a composition comprising a metal-organic hybrid structure formed by coordinate bond between a compound represented by the following Chemical Formula 1 or a salt thereof and a metal ion, with an acidic compound to be detected, wherein the composition is in the form of a metallogel prior to contact with the acidic compound, and detecting the acidic compound based on the transition of the composition from the form of a metallogel to a liquid phase. In some embodiments, detection of the acidic compound can be visually confirmed by phase transformation of the composition from a metallogel to a liquid phase.

A composition for detecting an acidic compound and a method using the same are discloses herein. In some embodiments, the method includes contacting a composition comprising a metal-organic hybrid structure formed by coordinate bond between a compound represented by the following Chemical Formula 1 or a salt thereof and a metal ion, with an acidic compound to be detected, wherein the composition is in the form of a metallogel prior to contact with the acidic compound, and detecting the acidic compound based on the transition of the composition from the form of a metallogel to a liquid phase. In some embodiments, detection of the acidic compound can be visually confirmed by phase transformation of the composition from a metallogel to a liquid phase.

It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.

It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.

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Modulators of caspase-6 activity are provided for use in the treatment of neurodegenerative diseases.

Provided herein are compounds that are prodrugs for mesalazine. Generally, the compounds described herein correspond to a mesalazine molecule wherein the amino group is replaced by a novel protecting group. For example, in the compounds of Formula I described herein, the compound comprises a glyoxylate derivative moiety. In the compounds of Formula II described herein, the compound comprises a vanillin derivative moiety.

Provided herein are compounds that are prodrugs for mesalazine. Generally, the compounds described herein correspond to a mesalazine molecule wherein the amino group is replaced by a novel protecting group. For example, in the compounds of Formula I described herein, the compound comprises a glyoxylate derivative moiety. In the compounds of Formula II described herein, the compound comprises a vanillin derivative moiety.

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One). ##STR00001##

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

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Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid of Formula (I), and methods for making such non-natural amino acids and polypeptides.