Methods and compositions are described herein that inhibit FAK/ATK interactions. Such methods and compositions are useful for inhibiting cell adhesion and cancer metastasis.

Methods and compositions are described herein that inhibit FAK/ATK interactions. Such methods and compositions are useful for inhibiting cell adhesion and cancer metastasis.

Provided is a compound represented by the following formula: ##STR00001##
Y.sup.1 to Y.sup.8 each represent a chemical single bond, O, S, OC(O), C(O)O, OC(O)O, NR.sup.1C(O), C(O)NR.sup.1, OC(O)NR.sup.1, NR.sup.1C(O)O, NR.sup.1C(O)NR.sup.1, ONR.sup.1, or NR.sup.1O, R.sup.1 being a hydrogen atom or an alkyl group having 1 to 6 carbon atoms. G.sup.1 and G.sup.2 each represent a divalent linear aliphatic group having 1 to 20 carbon atoms. that optionally includes O, S, OC(O), C(O)O, OC(O)O, NR.sup.3C(O), C(ONR.sup.3, NR.sup.3, or C(O). Z.sup.1 and Z.sup.2 each represent an alkenyl group having 2 to 10 carbon atoms. A.sup.1 represents a trivalent aromatic group. A.sup.2 and A.sup.3 each represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms. A.sup.4 and A.sup.5 each represents a divalent aromatic group having 6 to 30 carbon atoms. Q.sup.1 represents a alkyl group having 1 to 6 carbon atoms, an organic group having 2 to 30 carbon atoms that includes at least one of an aromatic hydrocarbon ring and a heteroaromatic ring, or a hydrogen atom. n and m each represent 0 or 1.

Provided is a compound represented by the following formula: ##STR00001##
Y.sup.1 to Y.sup.8 each represent a chemical single bond, O, S, OC(O), C(O)O, OC(O)O, NR.sup.1C(O), C(O)NR.sup.1, OC(O)NR.sup.1, NR.sup.1C(O)O, NR.sup.1C(O)NR.sup.1, ONR.sup.1, or NR.sup.1O, R.sup.1 being a hydrogen atom or an alkyl group having 1 to 6 carbon atoms. G.sup.1 and G.sup.2 each represent a divalent linear aliphatic group having 1 to 20 carbon atoms. that optionally includes O, S, OC(O), C(O)O, OC(O)O, NR.sup.3C(O), C(ONR.sup.3, NR.sup.3, or C(O). Z.sup.1 and Z.sup.2 each represent an alkenyl group having 2 to 10 carbon atoms. A.sup.1 represents a trivalent aromatic group. A.sup.2 and A.sup.3 each represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms. A.sup.4 and A.sup.5 each represents a divalent aromatic group having 6 to 30 carbon atoms. Q.sup.1 represents a alkyl group having 1 to 6 carbon atoms, an organic group having 2 to 30 carbon atoms that includes at least one of an aromatic hydrocarbon ring and a heteroaromatic ring, or a hydrogen atom. n and m each represent 0 or 1.

Methods and compositions are described herein that inhibit FAK/ATK interactions. Such methods and compositions are useful for inhibiting cell adhesion and cancer metastasis.

Methods and compositions are described herein that inhibit FAK/ATK interactions. Such methods and compositions are useful for inhibiting cell adhesion and cancer metastasis.

The present disclosure is directed to the synthesis and application of undecavertol derivatives having unique and desired flavor and/or fragrant characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions.

The present disclosure is directed to the synthesis and application of undecavertol derivatives having unique and desired flavor and/or fragrant characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions.

Provided is a compound represented by the following formula:

##STR00001##

Y.sup.1 to Y.sup.8 each represent a chemical single bond, O, S, OC(O), C(O)O, OC(O)O, NR.sup.1C(O), C(O)NR.sup.1, OC(O)NR.sup.1, NR.sup.1C(O)O, NR.sup.1C(O)NR.sup.1, ONR.sup.1, or NR.sup.1O, R.sup.1 being a hydrogen atom or an alkyl group having 1 to 6 carbon atoms. G.sup.1 and G.sup.2 each represent a divalent linear aliphatic group having 1 to 20 carbon atoms. that optionally includes O, S, OC(O), C(O)O, OC(O)O, NR.sup.3C(O), C(ONR.sup.3, NR.sup.3, or C(O). Z.sup.1 and Z.sup.2 each represent an alkenyl group having 2 to 10 carbon atoms. A.sup.1 represents a trivalent aromatic group. A.sup.2 and A.sup.3 each represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms. A.sup.4 and A.sup.5 each represents a divalent aromatic group having 6 to 30 carbon atoms. Q.sup.1 represents a alkyl group having 1 to 6 carbon atoms, an organic group having 2 to 30 carbon atoms that includes at least one of an aromatic hydrocarbon ring and a heteroaromatic ring, or a hydrogen atom. n and m each represent 0 or 1.

Provided is a compound represented by the following formula:

##STR00001##

Y.sup.1 to Y.sup.8 each represent a chemical single bond, O, S, OC(O), C(O)O, OC(O)O, NR.sup.1C(O), C(O)NR.sup.1, OC(O)NR.sup.1, NR.sup.1C(O)O, NR.sup.1C(O)NR.sup.1, ONR.sup.1, or NR.sup.1O, R.sup.1 being a hydrogen atom or an alkyl group having 1 to 6 carbon atoms. G.sup.1 and G.sup.2 each represent a divalent linear aliphatic group having 1 to 20 carbon atoms. that optionally includes O, S, OC(O), C(O)O, OC(O)O, NR.sup.3C(O), C(ONR.sup.3, NR.sup.3, or C(O). Z.sup.1 and Z.sup.2 each represent an alkenyl group having 2 to 10 carbon atoms. A.sup.1 represents a trivalent aromatic group. A.sup.2 and A.sup.3 each represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms. A.sup.4 and A.sup.5 each represents a divalent aromatic group having 6 to 30 carbon atoms. Q.sup.1 represents a alkyl group having 1 to 6 carbon atoms, an organic group having 2 to 30 carbon atoms that includes at least one of an aromatic hydrocarbon ring and a heteroaromatic ring, or a hydrogen atom. n and m each represent 0 or 1.