Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.

Provided herein are compounds for use as photochromic molecular switches having very long thermal isomerization half-lives and switchable fluorescence properties both in solution and the solid state.

Provided herein are compounds for use as photochromic molecular switches having very long thermal isomerization half-lives and switchable fluorescence properties both in solution and the solid state.

A compound which is represented by a formula (IIa), ##STR00001##
wherein each of Y.sup.1 to Y.sup.8 independently represents a chemical single bond, O, S, OC(O), C(O)O, OC(O)O, NR.sup.1C(O), C(O)NR.sup.1, OC(O)NR.sup.1, NR.sup.1C(O)O, NR.sup.1C(O)NR.sup.1, ONR.sup.1, or NR.sup.1O, R.sup.1 represents a hydrogen atom or an alkyl group; each of G.sup.1 and G.sup.2 independently represents a divalent linear aliphatic group; each of Z.sup.1 and Z.sup.2 independently represents an alkenyl group; A.sup.x represents a group represented by a formula (II), ##STR00002##
wherein X represents NR.sup.2, an oxygen atom, a sulfur atom, and R.sup.2 represents a hydrogen atom or an alkyl group; D represents an alkylene group or a cycloalkanediyl group; A.sup.1 represents a trivalent aromatic group; each of A.sup.2 and A.sup.3 independently represents a divalent alicyclic hydrocarbon group; each of A.sup.4 and A.sup.5 independently represents a divalent aromatic group; Q.sup.1 represents a hydrogen atom, or an alkyl group.

A compound which is represented by a formula (IIa), ##STR00001##
wherein each of Y.sup.1 to Y.sup.8 independently represents a chemical single bond, O, S, OC(O), C(O)O, OC(O)O, NR.sup.1C(O), C(O)NR.sup.1, OC(O)NR.sup.1, NR.sup.1C(O)O, NR.sup.1C(O)NR.sup.1, ONR.sup.1, or NR.sup.1O, R.sup.1 represents a hydrogen atom or an alkyl group; each of G.sup.1 and G.sup.2 independently represents a divalent linear aliphatic group; each of Z.sup.1 and Z.sup.2 independently represents an alkenyl group; A.sup.x represents a group represented by a formula (II), ##STR00002##
wherein X represents NR.sup.2, an oxygen atom, a sulfur atom, and R.sup.2 represents a hydrogen atom or an alkyl group; D represents an alkylene group or a cycloalkanediyl group; A.sup.1 represents a trivalent aromatic group; each of A.sup.2 and A.sup.3 independently represents a divalent alicyclic hydrocarbon group; each of A.sup.4 and A.sup.5 independently represents a divalent aromatic group; Q.sup.1 represents a hydrogen atom, or an alkyl group.

Provided herein are compounds for use as photochromic molecular switches having very long thermal isomerization half-lives and switchable fluorescence properties both in solution and the solid state.

Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.

Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.

A compound represented by a formula (IIa) is provided. In formula (IIa), Y.sup.1 to Y.sup.8 represent O, S, OC(O), C(O)O or the like, G.sup.1 and G.sup.2 represent a divalent linear aliphatic group having 1 to 20 carbon atoms or the like, Z.sup.1 and Z.sup.2 represent an alkenyl group having 2 to 10 carbon atoms or the like, A.sup.x represents a group represented by a formula (II), wherein X represents an oxygen atom, a sulfur atom or the like, D represents an alkylene group having 1 to 20 carbon atoms or the like, A.sup.1 represents a trivalent aromatic group or the like, A.sup.2 and A.sup.3 represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms or the like, A.sup.4 and A.sup.5 represent a divalent aromatic group having 4 to 30 carbon atoms or the like, Q.sup.1 represents an alkyl group having 1 to 6 carbon atoms or the like, and m and n are 0 or 1.

##STR00001##

A compound represented by a formula (IIa) is provided. In formula (IIa), Y.sup.1 to Y.sup.8 represent O, S, OC(O), C(O)O or the like, G.sup.1 and G.sup.2 represent a divalent linear aliphatic group having 1 to 20 carbon atoms or the like, Z.sup.1 and Z.sup.2 represent an alkenyl group having 2 to 10 carbon atoms or the like, A.sup.x represents a group represented by a formula (II), wherein X represents an oxygen atom, a sulfur atom or the like, D represents an alkylene group having 1 to 20 carbon atoms or the like, A.sup.1 represents a trivalent aromatic group or the like, A.sup.2 and A.sup.3 represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms or the like, A.sup.4 and A.sup.5 represent a divalent aromatic group having 4 to 30 carbon atoms or the like, Q.sup.1 represents an alkyl group having 1 to 6 carbon atoms or the like, and m and n are 0 or 1.

##STR00001##