A nitrogenous heterocyclic compound, a preparation method, an intermediate, a composition, and an application. The present invention provides a nitrogenous heterocyclic compound as represented by formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, diastereoisomers thereof, tautomers thereof, solvates thereof, metabolites thereof, or prodrugs thereof. The compound has high inhibitory activity against ErbB2 tyrosine kinase, has good inhibitory activity against human breast cancer cells BT-474, human gastric cancer cells NCI-N87 and the like with high expression of ErbB2, and in addition has relatively weak inhibitory activity against EGFR kinase, that is, the compound is an EGFR/ErbB2 double target inhibitor that attenuates EGFR kinase inhibitory activity or a small-molecule inhibitor having selectivity for an ErbB2 target. ##STR00001##

The present invention relates to 4-substituted phenylamidine derivatives of the general formula (I), wherein R5-R6, ArA4, D, G, B, Q and an integer m have the meanings as defined in the description. The invention further relates to methods for their preparation and use of said compounds for controlling undesired phytopathogenic microorganisms, and agents for said purpose, comprising said phenylamine derivatives. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted phenylamidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention.

The present invention relates to 4-substituted phenylamidine derivatives of the general formula (I), wherein R5-R6, ArA4, D, G, B, Q and an integer m have the meanings as defined in the description. The invention further relates to methods for their preparation and use of said compounds for controlling undesired phytopathogenic microorganisms, and agents for said purpose, comprising said phenylamine derivatives. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted phenylamidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention.

The present invention provides a method for controlling a soybean rust fungus having an amino acid substitution of F129L on mitochondrial cytochrome b protein. According to the present invention, a compound represented by formula (I) [wherein R.sup.1 represents a C1-C3 chain hydrocarbon group and so on, n is 0, 1, 2 or 3, and when is 2 or 3, a plural of R.sup.2 may be identical to or different from each other, and R.sup.2 represents a C1-C3 chain hydrocarbon group and so on, Q represents a group represented by Q1 (where • represents a binding site to a benzene ring) and so on, L.sup.1 represents CH.sub.2 or an oxygen atom, and E represents a C1-C6 alkyl group and so on.] can use to control a soybean rust fungus having an amino acid substitution of F129L on mitochondrial cytochrome b protein.

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A method for obtaining a salt with a general formula: R.sub.xNI, wherein: R.sub.xN is an organic cation (R.sub.xN.sup.+), R represents substituents (R−) independently selected from a group consisting of organic substituents: R.sup.1−, R.sup.2—, R.sup.3— and hydrogen (H—), x is a number of the substituents R— directly linked with the nitrogen (N) atom in the organic cation R.sub.xN.sup.+, wherein x is 3 or 4, I is an iodide anion (I.sup.−). The method comprises: preparing a reaction mixture comprising the steps of: synthesizing hydrogen iodide (HI) in situ by mixing molecular iodine (I.sub.2) with formic acid (COOH) in a molar ratio of molecular iodine (I.sub.2): formic acid (COOH) of no less than 1.01:1, in a solvent medium, introducing into the solvent medium a compound being a donor of organic cation R.sub.xN.sup.+ in an amount providing the molar ratio of the donor of organic cation R.sub.xN.sup.+: molecular iodine (I.sub.2) of no less than 1.01:1, and maintaining the reaction mixture at a temperature of not less than 20° C. for the time necessary to obtain the reaction product being the salt with the general formula R.sub.xNI. The obtained product is a substrate for synthesis of perovskites.

A method for obtaining a salt with a general formula: R.sub.xNI, wherein: R.sub.xN is an organic cation (R.sub.xN.sup.+), R represents substituents (R−) independently selected from a group consisting of organic substituents: R.sup.1−, R.sup.2—, R.sup.3— and hydrogen (H—), x is a number of the substituents R— directly linked with the nitrogen (N) atom in the organic cation R.sub.xN.sup.+, wherein x is 3 or 4, I is an iodide anion (I.sup.−). The method comprises: preparing a reaction mixture comprising the steps of: synthesizing hydrogen iodide (HI) in situ by mixing molecular iodine (I.sub.2) with formic acid (COOH) in a molar ratio of molecular iodine (I.sub.2): formic acid (COOH) of no less than 1.01:1, in a solvent medium, introducing into the solvent medium a compound being a donor of organic cation R.sub.xN.sup.+ in an amount providing the molar ratio of the donor of organic cation R.sub.xN.sup.+: molecular iodine (I.sub.2) of no less than 1.01:1, and maintaining the reaction mixture at a temperature of not less than 20° C. for the time necessary to obtain the reaction product being the salt with the general formula R.sub.xNI. The obtained product is a substrate for synthesis of perovskites.

Lanthanide compounds for vapor deposition having ≤50.0 ppm, ≤30.0 ppm, or ≤10.0 ppm of all halide impurity combined is provided. The purification systems and methods are also provided.

Lanthanide compounds for vapor deposition having ≤50.0 ppm, ≤30.0 ppm, or ≤10.0 ppm of all halide impurity combined is provided. The purification systems and methods are also provided.

An organic-inorganic perovskite satisfying E.sub.T<E.sub.T1 and E.sub.S-E.sub.T≤0.1 eV has a high emission efficiency. E.sub.S represents the excited singlet energy level in emission of an inorganic component, E.sub.T represents the excited triplet energy level in emission of an inorganic component, E.sub.T1 represents the excited triplet energy level in emission of an organic component.

This disclosure relates to aryl amidines of Formula I and their use as fungicides.

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