Disclosed are ROS-sensitive NOS inhibitors, as well as methods of making and using the same.

The present invention relates to a novel process for preparing chlorobenzaldehyde oximes of the general formula (I).

The present invention relates to a method for preparing dihydroxyammonium 5,5-bistetrazole-1,1-diolate. The method for preparing dihydroxyammonium 5,5-bistetrazole-1,1-diolate, according to one embodiment of the present invention, comprises the steps of: synthesizing 5,5-bistetrazole-1,1-diol dihydrate (1,1-BTO) from ditetrahydropyranyl diazidoglyoxime (THP-DAG) by using a hydrochloric acid (HCl) solution in a first solvent; and reacting 1,1-BTO with an amine solution so as to neutralize same and, simultaneously, obtaining dihydroxylammonium 5,5-bistetrazole-1,1-diolate (Thomas Klapotke explosive-50, TKX-50).

The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of labelling a biological targeting molecule with a radioisotope. The method of the invention is particularly suitable for use with an automated synthesizer apparatus. Also provided are precursors in sterile form, as well as cassettes comprising such precursors useful in the method.

The present invention relates to a novel process for preparing chlorobenzaldehyde oximes of the general formula (I).

The present invention relates to a novel process for preparing chlorobenzaldehyde oximes of the general formula (I).