A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R.sub.3 are in vicinal position (if m=0 then R.sub.3 is in position 2′, and if m=1 then R.sup.3 is on position 1′); R is ethyl or vinyl; R.sub.1 is hydrogen or (C1-6)alkyl; R.sub.2 is hydrogen or—(C.sub.3-6)cycloalkyl, or—unsubstituted (C.sub.1-6)alkyl, or—(C.sub.1-6)alkyl substituted by one or more of—hydroxy; preferably one or two,—methoxy,—halogen,—(C.sub.3-6)cycloalkyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e. g. selected from N or O, or R.sub.1 is hydroxy and R.sub.2 is formyl; R.sub.3 is OH, OR.sub.4, a halogen atom, or—with the proviso that R.sub.3 is bound to 2′ R.sub.3 represents —O—(CH.sub.2)P—O— with p is 2 or 3; R.sub.4 is unsubstituted (C.sub.1-6)alkyl or (C.sub.3-6)cycloalkyl.

A compound having the following formula (I): ##STR00001##
is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed

##STR00001##

Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed

##STR00001##

The present invention is directed to novel pleuromutilin antibiotic compounds, intermediates which are useful for making these novel antibiotic compounds, methods of synthesizing these compounds and related methods and pharmaceutical compositions for treating pathogens» especially bacterial infections, including gram negative bacteria.

Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed:

##STR00001##

The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate.

##STR00001##

A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R.sub.3 are in vicinal position (if m=0 then R.sub.3 is in position 2, and if m=1 then R.sup.3 is on position 1); R is ethyl or vinyl; R.sub.1 is hydrogen or (C1-6)alkyl; R.sub.2 is hydrogen or (C.sub.3-6)cycloalkyl, or unsubstituted (C.sub.1-6)alkyl, or (C.sub.1-6)alkyl substituted by one or more of hydroxy; preferably one or two, methoxy, halogen, (C.sub.3-6)cycloalkyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e.g. selected from N or O, or R.sub.1 is hydroxy and R.sub.2 is formyl; R.sub.3 is OH, OR.sub.4, a halogen atom, or with the proviso that R.sub.3 is bound to 2 R.sub.3 represents O(CH.sub.2)PO with p is 2 or 3; R.sub.4 is unsubstituted (C.sub.1-6)alkyl or (C.sub.3-6)cycloalkyl.

Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed:

##STR00001##

Provided are a novel compound and an organic electronic device using the same. The novel compound is represented by the following Formula (I): ##STR00001##