A process for producing hydrogen-lean syngas includes the steps of reacting, via a catalytic partial oxidation (CPO) reaction, a CPO reactant mixture in a CPO reactor to produce the hydrogen-lean syngas, wherein the CPO reactant mixture includes hydrocarbons and oxygen. The hydrocarbons include greater than or equal to about 3 mol % C2+ alkanes, wherein the CPO reactor include a CPO catalyst, and wherein the hydrogen-lean syngas include hydrogen, carbon monoxide, carbon dioxide, water, and unreacted hydrocarbons The hydrogen-lean syngas is characterized by a molar ratio of hydrogen to carbon monoxide (H2/CO) in a range of from about 0.8 to about 1.6. A system for carrying out the process is also provided.

A process for producing hydrogen-lean syngas includes the steps of reacting, via a catalytic partial oxidation (CPO) reaction, a CPO reactant mixture in a CPO reactor to produce the hydrogen-lean syngas, wherein the CPO reactant mixture includes hydrocarbons and oxygen. The hydrocarbons include greater than or equal to about 3 mol % C2+ alkanes, wherein the CPO reactor include a CPO catalyst, and wherein the hydrogen-lean syngas include hydrogen, carbon monoxide, carbon dioxide, water, and unreacted hydrocarbons The hydrogen-lean syngas is characterized by a molar ratio of hydrogen to carbon monoxide (H2/CO) in a range of from about 0.8 to about 1.6. A system for carrying out the process is also provided.

A process for producing hydrogen-lean syngas includes the steps of reacting, via a catalytic partial oxidation (CPO) reaction, a CPO reactant mixture in a CPO reactor to produce the hydrogen-lean syngas, wherein the CPO reactant mixture includes hydrocarbons and oxygen. The hydrocarbons include greater than or equal to about 3 mol % C2+ alkanes, wherein the CPO reactor include a CPO catalyst, and wherein the hydrogen-lean syngas include hydrogen, carbon monoxide, carbon dioxide, water, and unreacted hydrocarbons The hydrogen-lean syngas is characterized by a molar ratio of hydrogen to carbon monoxide (H2/CO) in a range of from about 0.8 to about 1.6. A system for carrying out the process is also provided.

The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.

The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.