A novel urea (meth)acrylate can be prepared by a process involving reacting a urea containing alcohol or amine with a (meth)acrylate, (meth)acryloyl chloride, (meth)acrylic acid, or (meth)acrylic anhydride. A binder composition includes at least one repeating unit derived from the urea (meth)acrylate. The binder composition can be used in adhesive and coating applications.

A novel urea (meth)acrylate can be prepared by a process involving reacting a urea containing alcohol or amine with a (meth)acrylate, (meth)acryloyl chloride, (meth)acrylic acid, or (meth)acrylic anhydride. A binder composition includes at least one repeating unit derived from the urea (meth)acrylate. The binder composition can be used in adhesive and coating applications.

The present invention relates to a urea and urethane group containing product comprising one or more species of formula (I) R.sup.1O(CO)NHR.sup.2NH(CO)NHR.sup.3NH[(CO)NHR.sup.4NH(CO)NHR.sup.3NH].sub.n(CO)NHR.sup.2NH(CO)OR.sup.1 (I), wherein R.sup.1 independently represents a non-aromatic hydrocarbyl group having 14 to 30 carbon atoms; R.sup.2 independently represents alkyl-substituted aromatic hydrocarbyl groups having 7 to 12 carbon atoms; R.sup.3 independently represents hydrocarbyl groups having 2 to 36 carbon atoms, which can be interrupted by 1 to 17 ether oxygen atoms in case of aliphatic hydrocarbyl groups; R.sup.4 independently represents hydrocarbyl groups having 2 to 36 carbon atoms; n is an integer from 0 to 200; and wherein on average from 40 mol-% to 100 mol-% of all R.sup.3 and R.sup.4 groups contained in the one or more species of formula (I) are acyclic aliphatic hydrocarbyl groups which, in case of R.sup.3, can be interrupted by 1 to 17 ether oxygen atoms. The invention further relates to a method of manufacturing such product, liquid compositions containing such products and the use of the liquid compositions as rheology control additive, preferably as anti-settling agent. Furthermore, the present invention relates to a process for rheology adjustment, comprising the step of adding such liquid composition to a variety of compositions and formulations.

The present invention relates to a urea and urethane group containing product comprising one or more species of formula (I) R.sup.1O(CO)NHR.sup.2NH(CO)NHR.sup.3NH[(CO)NHR.sup.4NH(CO)NHR.sup.3NH].sub.n(CO)NHR.sup.2NH(CO)OR.sup.1 (I), wherein R.sup.1 independently represents a non-aromatic hydrocarbyl group having 14 to 30 carbon atoms; R.sup.2 independently represents alkyl-substituted aromatic hydrocarbyl groups having 7 to 12 carbon atoms; R.sup.3 independently represents hydrocarbyl groups having 2 to 36 carbon atoms, which can be interrupted by 1 to 17 ether oxygen atoms in case of aliphatic hydrocarbyl groups; R.sup.4 independently represents hydrocarbyl groups having 2 to 36 carbon atoms; n is an integer from 0 to 200; and wherein on average from 40 mol-% to 100 mol-% of all R.sup.3 and R.sup.4 groups contained in the one or more species of formula (I) are acyclic aliphatic hydrocarbyl groups which, in case of R.sup.3, can be interrupted by 1 to 17 ether oxygen atoms. The invention further relates to a method of manufacturing such product, liquid compositions containing such products and the use of the liquid compositions as rheology control additive, preferably as anti-settling agent. Furthermore, the present invention relates to a process for rheology adjustment, comprising the step of adding such liquid composition to a variety of compositions and formulations.

The present invention relates to an improved process of preparation of idelalisib using a solid form of intermediate of formula (2);

##STR00001##

characterized by XRPD pattern having 2 values 5.5, 10.9, 14.3, 16.9 (0.2) the process comprising steps a. Reacting of compound of formula (1);

##STR00002## with a chlorinating agent to obtain a product; b. Reacting of the product with (S)-2-((tert-butoxycarbonyl)amino)butanoic acid and a base, wherein pH of the reaction mixture is set between 7.5 and 10 to obtain compound of formula (2); c. Isolating a solid form of compound of formula (2);

##STR00003## d. Transforming the compound of formula (2) into idelalisib.

A method for producing an alkylamine derivative having a urea bond represented by formula (I), or a salt thereof, comprises the following steps (a) and (b), step (a):

##STR00001##

and step (b): deprotecting as necessary the reaction product obtained in step (a). The production method suitable for industrialization of the alkylamine derivative having a urea bond represented by formula (I), which is a compound highly useful as an agent having CaSR agonist effects is provided.

A method for producing an alkylamine derivative having a urea bond represented by formula (I), or a salt thereof, comprises the following steps (a) and (b), step (a):

##STR00001##

and step (b): deprotecting as necessary the reaction product obtained in step (a). The production method suitable for industrialization of the alkylamine derivative having a urea bond represented by formula (I), which is a compound highly useful as an agent having CaSR agonist effects is provided.

A novel urea (meth)acrylate can be prepared by a process involving reacting a urea containing alcohol or amine with a (meth)acrylate, (meth)acryloyl chloride, (meth)acrylic acid, or (meth)acrylic anhydride. A binder composition includes at least one repeating unit derived from the urea (meth)acrylate. The binder composition can be used in adhesive and coating applications.

A novel urea (meth)acrylate can be prepared by a process involving reacting a urea containing alcohol or amine with a (meth)acrylate, (meth)acryloyl chloride, (meth)acrylic acid, or (meth)acrylic anhydride. A binder composition includes at least one repeating unit derived from the urea (meth)acrylate. The binder composition can be used in adhesive and coating applications.