The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound:

##STR00001## wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R.sub.1 and R.sub.2 are independently H— or alkyl; R.sub.3 is H—, alkyl or aralkyl; and R.sub.4 is H— or aryl.

The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound:

##STR00001## wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R.sub.1 and R.sub.2 are independently H— or alkyl; R.sub.3 is H—, alkyl or aralkyl; and R.sub.4 is H— or aryl.

Provided is a photo-curable composition capable of creating a three-dimensional object excellent in both of: stiffness and strength; and toughness. Specifically, provided is a photo-curable composition including: a blocked isocyanate represented by the general formula (1); a chain extender; and a photo-radical generator: ##STR00001##
wherein, in the general formula (1), A.sub.1 to A.sub.4 each independently represent a structure represented by the following general formula (2), and B represents a structure represented by the following general formula (3) ##STR00002##

Provided is a photo-curable composition capable of creating a three-dimensional object excellent in both of: stiffness and strength; and toughness. Specifically, provided is a photo-curable composition including: a blocked isocyanate represented by the general formula (1); a chain extender; and a photo-radical generator: ##STR00001##
wherein, in the general formula (1), A.sub.1 to A.sub.4 each independently represent a structure represented by the following general formula (2), and B represents a structure represented by the following general formula (3) ##STR00002##

Compounds of Formula (I) or (X) are provided including for treatment of disorders such as a disorder or symptom associated with neuronal cell death. In one aspect, compounds which are selective inhibitors of calpain-2 are provided. Preferred compounds can be useful to treat acute neurodegeneration.

The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: ##STR00001## wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R.sub.1 and R.sub.2 are independently H— or alkyl; R.sub.3 is H—, alkyl or aralkyl; and R.sub.4 is H— or aryl.

The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: ##STR00001## wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R.sub.1 and R.sub.2 are independently H— or alkyl; R.sub.3 is H—, alkyl or aralkyl; and R.sub.4 is H— or aryl.

Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate N-methyl-N′-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide of formula (III)

##STR00001## wherein intermediate (III) is obtained via a novel intermediate without the use of potentially hazardous reagents or potentially unstable intermediates.

The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound:

##STR00001## wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R.sub.1 and R.sub.2 are independently H— or alkyl; R.sub.3 is H—, alkyl or aralkyl; and R.sub.4 is H— or aryl.

The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound:

##STR00001## wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R.sub.1 and R.sub.2 are independently H— or alkyl; R.sub.3 is H—, alkyl or aralkyl; and R.sub.4 is H— or aryl.