The present invention provides a crystalline salt of chlorhexidine chloride having a spherical morphology under Scanning Electron Microscopy (SEM) comprising a chloride anion and a cation selected from the group consisting of calcium, sodium, potassium, magnesium, zinc, strontium or iron, processes for the preparation of the salt, compositions, pharmaceutical compositions and uses thereof in medicine. Also provided are crystalline forms of the salt and fibres comprising the same.

Metformin salts of 2,4-thiazolidinediones are described for the treatment of diabetes mellitus Type2, gestational diabetes, polycystic ovary syndrome, non-alcoholic fatty liver disease, coronary artery disease, pancreatic cancer, premature puberty, and other diseases which manifest insulin resistance.

The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C.sub.22H.sub.32Cl.sub.2N.sub.10][C.sub.6H.sub.12NO.sub.3S].sub.2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.

This disclosure relates to methods of managing cancer using bis-biguanide compounds, such as alexidine, and pharmaceutical compositions comprising the same. In certain embodiments, this disclosure relates to methods of treating lung cancer comprising administering an effective amount of a bis-biguanide compound to a subject in need thereof. In certain embodiments, this disclosure relates to methods of treating small cell lung cancer comprising administering an effective amount of a bis-biguanide compound to a subject in need thereof. In certain embodiments, the subject is diagnosed with a lung cancer. In certain embodiments, the subject is diagnosed with small cell lung cancer. In certain embodiments, the subject is a human subject.

Novel tris-substituted biguanide compounds are made by reaction of sodium dicyanamide with a trifunctional primary amine followed by reaction with anilines. The tris-substituted biguanide compounds are potent biocide and useful as a disinfectant. The novel compounds have biocidal activity comparable to those of widely used chlorhexidine with respect to width of antibacterial spectrum and in immediate effectiveness. The novel tris-substituted biguanide compounds can also be used for cleaning wounds, preventing dental plaque, treating yeast infections of the mouth, and to keep urinary catheters from blocking, These novel compounds have superior aqueous solubility and bioavailability and have potent antibacterial activity especially against A. baumanni and K. pneumonia.

A polyguanidine biocidal compound miscible with an anionic surfactant. PHMG and PHMB are modified with a variety of different carboxylic acids. Carboxyl groups are added to the ends of the linear polyguanidine chain giving them the structure and properties of an amphoteric surfactant. The modified polyguanidine is now miscible with anionic surfactants while retaining the original bactericidal properties. In this way, it can be compounded with modified polyguanidine and anionic surfactant to produce a product with both sterilization and decontamination properties that is usable in daily use products, and industrial and agricultural fields. A method of manufacturing a polyguanidine biocidal compound is also provided.

A polyguanidine biocidal compound miscible with an anionic surfactant. PHMG and PHMB are modified with a variety of different carboxylic acids. Carboxyl groups are added to the ends of the linear polyguanidine chain giving them the structure and properties of an amphoteric surfactant. The modified polyguanidine is now miscible with anionic surfactants while retaining the original bactericidal properties. In this way, it can be compounded with modified polyguanidine and anionic surfactant to produce a product with both sterilization and decontamination properties that is usable in daily use products, and industrial and agricultural fields. A method of manufacturing a polyguanidine biocidal compound is also provided.

The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C.sub.22H.sub.32Cl.sub.2N.sub.10][C.sub.6H.sub.12NO.sub.3S].sub.2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.

The present invention relates to new compounds of formula (I), and their uses.

##STR00001##

The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C.sub.22H.sub.32Cl.sub.2N.sub.10][C.sub.6H.sub.12NO.sub.3S].sub.2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.