Patent classifications
C07C311/45
Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I),
##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I),
##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I), ##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I), ##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I), ##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I), ##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I), ##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I), ##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I), ##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
- Robert J. Altenbach ,
- Andrew Bogdan ,
- Sylvain Couty ,
- Nicolas Desroy ,
- Gregory A. Gfesser ,
- Christopher Gaëtan Housseman ,
- Philip R. Kym ,
- Bo Liu ,
- Thi Thu Trang Mai ,
- Karine Fabienne Malagu ,
- Nuria Merayo Merayo ,
- Olivier Laurent Picolet ,
- Mathieu Rafaël Pizzonero ,
- Xenia B. Searle ,
- Steven Emiel Van der Plas ,
- Xueqing Wang ,
- Ming C. Yeung
The invention discloses compounds of Formula (I), ##STR00001##
wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.