The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R′)-3,3′-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R′)-3,3′-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

The invention relates to a process for the co-production of methyl mercaptan and of dimethyl disulfide, comprising the following successive steps: a) reaction of at least one carbon oxide in the presence of hydrogen sulfide (H.sub.2S) and hydrogen to form a stream (M) comprising methyl mercaptan, water, and possibly unreacted hydrogen sulfide, b) purification of the stream (M) to obtain a stream (N) enriched in methyl mercaptan and a stream containing the uncondensable compounds (M.sub.uncond), c) optional recycling of the stream of uncondensable compounds (M.sub.uncond) obtained from step b) into step a), d) recovery of a first portion of the stream (N) including methyl mercaptan purified in step b), e) oxidation with sulfur of the second portion of the stream (N) of methyl mercaptan, to form a stream (O) comprising dimethyl disulfide, hydrogen sulfide, and possibly unreacted methyl mercaptan, f) purification of the stream (O) to separate, on the one hand, the enriched dimethyl disulfide and, on the other hand, the hydrogen sulfide and possibly the methyl mercaptan that has not reacted in step e), g) recycling of the hydrogen sulfide and possibly of the methyl mercaptan isolated in step f) into the stream (M) obtained from step a), h) recovery of the dimethyl disulfide isolated in step f).

The invention relates to a process for the co-production of methyl mercaptan and of dimethyl disulfide, comprising the following successive steps: a) reaction of at least one carbon oxide in the presence of hydrogen sulfide (H.sub.2S) and hydrogen to form a stream (M) comprising methyl mercaptan, water, and possibly unreacted hydrogen sulfide, b) purification of the stream (M) to obtain a stream (N) enriched in methyl mercaptan and a stream containing the uncondensable compounds (M.sub.uncond), c) optional recycling of the stream of uncondensable compounds (M.sub.uncond) obtained from step b) into step a), d) recovery of a first portion of the stream (N) including methyl mercaptan purified in step b), e) oxidation with sulfur of the second portion of the stream (N) of methyl mercaptan, to form a stream (O) comprising dimethyl disulfide, hydrogen sulfide, and possibly unreacted methyl mercaptan, f) purification of the stream (O) to separate, on the one hand, the enriched dimethyl disulfide and, on the other hand, the hydrogen sulfide and possibly the methyl mercaptan that has not reacted in step e), g) recycling of the hydrogen sulfide and possibly of the methyl mercaptan isolated in step f) into the stream (M) obtained from step a), h) recovery of the dimethyl disulfide isolated in step f).

Provided herein are molecules and salts thereof, arrays containing molecules and salts thereof, solid supports containing molecules and salts thereof, kits containing molecules or salts thereof, and methods of determining alignment of photolithographic masks comprising molecules or salts thereof.

Provided herein are molecules and salts thereof, arrays containing molecules and salts thereof, solid supports containing molecules and salts thereof, kits containing molecules or salts thereof, and methods of determining alignment of photolithographic masks comprising molecules or salts thereof.

Provided herein are molecules and salts thereof, arrays containing molecules and salts thereof, solid supports containing molecules and salts thereof, kits containing molecules or salts thereof, and methods of determining alignment of photolithographic masks comprising molecules or salts thereof.

The present disclosure relates to the field of synthesis of mercapto compounds, and in particular, to a preparation method of 3-mercaptopropionic acid. The preparation method provided by the present disclosure comprises the steps of: mixing sodium acrylate with sodium hydrosulfide or sodium sulfide for reacting; adding sodium sulfide (or adding sodium sulfide and sulfur powder) for further reacting; crystallizing, and acidifying with an acid to obtain a solution of 3-mercaptopropionic acid. According to the preparation method provided by the present disclosure, the raw materials are inexpensive, the product 3-mercaptopropionic acid can be obtained with a high yield and high purity, moreover, and solid waste and solvent(s) can be separated and recovered; sodium salt can be used as an industrial product after crystallization; the solvent(s) can be recovered and recycled by distillation; and disposal of three wastes is simple.

The present disclosure relates to the field of synthesis of mercapto compounds, and in particular, to a preparation method of 3-mercaptopropionic acid. The preparation method provided by the present disclosure comprises the steps of: mixing sodium acrylate with sodium hydrosulfide or sodium sulfide for reacting; adding sodium sulfide (or adding sodium sulfide and sulfur powder) for further reacting; crystallizing, and acidifying with an acid to obtain a solution of 3-mercaptopropionic acid. According to the preparation method provided by the present disclosure, the raw materials are inexpensive, the product 3-mercaptopropionic acid can be obtained with a high yield and high purity, moreover, and solid waste and solvent(s) can be separated and recovered; sodium salt can be used as an industrial product after crystallization; the solvent(s) can be recovered and recycled by distillation; and disposal of three wastes is simple.

The present disclosure relates to the field of synthesis of mercapto compounds, and in particular, to a preparation method of 3-mercaptopropionic acid. The preparation method provided by the present disclosure comprises the steps of: mixing sodium acrylate with sodium hydrosulfide or sodium sulfide for reacting; adding sodium sulfide (or adding sodium sulfide and sulfur powder) for further reacting; crystallizing, and acidifying with an acid to obtain a solution of 3-mercaptopropionic acid. According to the preparation method provided by the present disclosure, the raw materials are inexpensive, the product 3-mercaptopropionic acid can be obtained with a high yield and high purity, moreover, and solid waste and solvent(s) can be separated and recovered; sodium salt can be used as an industrial product after crystallization; the solvent(s) can be recovered and recycled by distillation; and disposal of three wastes is simple.