The present invention relates to the field of compounds, and in particular to a probucol derivative, a preparation method therefor and use thereof, the probucol derivative having a structure represented by general formula I. The probucol derivative provided in the present invention can be used for the prevention and treatment of vascular diseases including diabetes, cardio-cerebrovascular diseases or complications thereof, and can be effectively used for reducing blood glucose, reducing blood lipid, reducing cholesterol, reducing body weight, reducing triglyceride, anti-inflammatory, and anti-oxidation, etc., having broad prospective applications. ##STR00001##

The present invention provides a compound of Formula I, II or III or a salt or prodrug or derivative thereof that is useful for skin-whitening by inhibiting melanin formation and removing existing melanin and the inhibition of melanoma growth and/or the removal of existing melanoma cells.

The present invention provides a compound of Formula I, II or III or a salt or prodrug or derivative thereof that is useful for skin-whitening by inhibiting melanin formation and removing existing melanin and the inhibition of melanoma growth and/or the removal of existing melanoma cells.

Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate N-methyl-N′-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide of formula (III)

##STR00001## wherein intermediate (III) is obtained via a novel intermediate without the use of potentially hazardous reagents or potentially unstable intermediates.

Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate N-methyl-N′-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide of formula (III)

##STR00001## wherein intermediate (III) is obtained via a novel intermediate without the use of potentially hazardous reagents or potentially unstable intermediates.

Described herein are compounds of Formulas I-XIII and agrochemically acceptable salts thereof having herbicidal and fungicidal activity. Also disclosed herein are herbicidal and fungicidal compositions, including compounds of Formula I-XIII or agrochemically acceptable salts thereof, and methods of controlling unwanted vegetation or fungus using compositions including the compound of Formula I-XIII or an agrochemically acceptable salt thereof.

Described herein are compounds of Formulas I-XIII and agrochemically acceptable salts thereof having herbicidal and fungicidal activity. Also disclosed herein are herbicidal and fungicidal compositions, including compounds of Formula I-XIII or agrochemically acceptable salts thereof, and methods of controlling unwanted vegetation or fungus using compositions including the compound of Formula I-XIII or an agrochemically acceptable salt thereof.

A sulfoxide compound and method of producing benzothiophene derivatives using the same are provided. The sulfoxide compound is represented by formula (I), wherein R.sub.1 and R.sub.2 are individually and independently benzoyl group; alkyl, acyl or silyl group of C.sub.1-C.sub.6 straight chain or branched chain; or alkenyl group of C.sub.3-C.sub.6 straight chain or branched chain; and X is halogen atom. The sulfoxide compound reacts with alkynyl compound, and then the synthesis efficiency of benzothiophene derivatives can be effectively increased. ##STR00001##

In one aspect, the invention provides a method of promoting a carbon-sulfur bond forming reaction. In certain embodiments, the reaction comprises cross-coupling of a(n) (hetero)aryl halide with a thiol to form the carbon-sulfur bond, wherein the method is promoted by light irradiation in the absence of a photocatalyst. In other embodiments, the cross-coupling reaction can be promoted through visible light irradiation, including sunlight.

In one aspect, the invention provides a method of promoting a carbon-sulfur bond forming reaction. In certain embodiments, the reaction comprises cross-coupling of a(n) (hetero)aryl halide with a thiol to form the carbon-sulfur bond, wherein the method is promoted by light irradiation in the absence of a photocatalyst. In other embodiments, the cross-coupling reaction can be promoted through visible light irradiation, including sunlight.