The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.

Compounds of formula I ##STR00001##
a process for preparation of compounds of formula I; precursor compounds of formula II ##STR00002##
a process for preparation of precursor compounds of formula II; compounds of formula III ##STR00003##
a process for the preparation of compounds of formula IV from compounds of formula III ##STR00004##
and the use of compounds of formula I for the preparation of compounds of formula IV.

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

Compounds of formula I

##STR00001##

a process for preparation of compounds of formula I; precursor compounds of formula II

##STR00002##

a process for preparation of precursor compounds of formula II; compounds of formula III

##STR00003##

a process for the preparation of compounds of formula IV from compounds of formula III

##STR00004##

and the use of compounds of formula I for the preparation of compounds of formula IV.

Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.

Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.

Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.

The present disclosure provides compounds of Formula (VIIb) and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer. ##STR00001##