Cannabidiol derivatives and medical use thereof, in particular to the compounds represented by general formula (I), or stereoisomers, solvates, metabolites, prodrugs, pharmaceutically acceptable salts or cocrystals thereof, wherein the definitions of substituents in general formula (I) are the same as those in the description

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Cannabidiol derivatives and medical use thereof, in particular to the compounds represented by general formula (I), or stereoisomers, solvates, metabolites, prodrugs, pharmaceutically acceptable salts or cocrystals thereof, wherein the definitions of substituents in general formula (I) are the same as those in the description

##STR00001##

Disclosed is a method for converting a first cannabinoid into a second cannabinoid that is a regioisomer of the first cannabinoid. The method comprising contacting the first cannabinoid with: (i) a base having a pKb that is less than a critical pKb for the first cannabinoid; and (ii) a solvent system comprising a polar solvent such as dimethyl sulfoxide (DMSO), triethylamine (TEA), or a combination thereof.

Disclosed is a method for converting a first cannabinoid into a second cannabinoid that is a regioisomer of the first cannabinoid. The method comprising contacting the first cannabinoid with: (i) a base having a pKb that is less than a critical pKb for the first cannabinoid; and (ii) a solvent system comprising a polar solvent such as dimethyl sulfoxide (DMSO), triethylamine (TEA), or a combination thereof.

Disclosed are a spiro-bisphosphorous compound, and a preparation and application thereof. The spiro-bisphosphorous compound is expressed in formula (I), (II) or (III).

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Disclosed are a spherical titanium silicalite catalyst and a preparation method therefor. The spherical titanium silicalite catalyst has the following composition: xTiO.sub.2.Math.(1?x)SiO.sub.2/yMPO.sub.4, wherein x is equal to 0.0005-0.04, y is equal to 0.005-0.20, M is a metal element selected from alkaline earth metals, transition metals or combinations of two or more thereof. The spherical titanium silicalite catalyst is prepared by the following method: (i) providing titanium silicalite raw powder with the composition of xTiO.sub.2.Math.(1?x)SiO.sub.2, wherein x is equal to 0.0005-0.04, and y is equal to 0.005-0.20; (ii) mixing silica sol, an organic template agent and phosphate in proportion to obtain an adhesive; and (iii) mixing the adhesive with the titanium silicalite raw powder, and carrying out spray-drying molding and firing to obtain the titanium silicalite catalyst.

The present invention relates to a method for preparing substituted styrene derivatives.

The present invention relates to a method for preparing substituted styrene derivatives.

The present invention relates to a method for preparing substituted styrene derivatives.

The present invention relates to a method for preparing substituted styrene derivatives.