The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging and therapeutic agents when bound to an appropriate metal centre, particularly for the imaging of tumours.

The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging and therapeutic agents when bound to an appropriate metal centre, particularly for the imaging of tumours.

A tetracarbonyl cyclobutene dihydrate compound, having a chemical formula (1).

##STR00001##

A method of synthesizing the tetracarbonyl cyclobutene dihydrate compound, includes: a synthesis step, a separation step, and a purification step. The synthesis step includes: collecting and dissolving 0.5728 g of squaric acid, 2.7948 g of ammonium formate, and 0.0480 g of the palladium complex in 100 mL of anhydrous methanol, heating and stirring a resulting mixture to reflux for 48 hrs, and stopping the reaction. The separation step includes: performing column chromatography analysis on reaction products according to a volume ratio of dichloromethane to anhydrous methanol of 8:2, to obtain a target product. A method of using the tetracarbonyl cyclobutene dihydrate compound, includes: using tetracarbonyl cyclobutene dihydrate compound as a catalyst in addition reaction between ethyl pyruvate and nitromethane, where a conversion rate of ethyl pyruvate reaches 96.1%.

A tetracarbonyl cyclobutene dihydrate compound, having a chemical formula (1).

##STR00001##

A method of synthesizing the tetracarbonyl cyclobutene dihydrate compound, includes: a synthesis step, a separation step, and a purification step. The synthesis step includes: collecting and dissolving 0.5728 g of squaric acid, 2.7948 g of ammonium formate, and 0.0480 g of the palladium complex in 100 mL of anhydrous methanol, heating and stirring a resulting mixture to reflux for 48 hrs, and stopping the reaction. The separation step includes: performing column chromatography analysis on reaction products according to a volume ratio of dichloromethane to anhydrous methanol of 8:2, to obtain a target product. A method of using the tetracarbonyl cyclobutene dihydrate compound, includes: using tetracarbonyl cyclobutene dihydrate compound as a catalyst in addition reaction between ethyl pyruvate and nitromethane, where a conversion rate of ethyl pyruvate reaches 96.1%.

Compositions and methods that can increase or stimulate hair growth, as well as novel chemicals that affect hair growth and hair loss.

A tetracarbonyl cyclobutene dihydrate compound, having a chemical formula (I). ##STR00001## A method of synthesizing the tetracarbonyl cyclobutene dihydrate compound, includes: a synthesis step, a separation step, and a purification step. The synthesis step includes: collecting and dissolving 0.5728 g of squaric acid, 2.7948 g of ammonium formate, and 0.0480 g of the palladium complex in 100 mL of anhydrous methanol, heating and stirring a resulting mixture to reflux for 48 hrs, and stopping the reaction. The separation step includes: performing column chromatography analysis on reaction products according to a volume ratio of dichloromethane to anhydrous methanol of 8:2, to obtain a target product. A method of using the tetracarbonyl cyclobutene dihydrate compound, includes: using tetracarbonyl cyclobutene dihydrate compound as a catalyst in addition reaction between ethyl pyruvate and nitromethane, where a conversion rate of ethyl pyruvate reaches 96.1%.

A tetracarbonyl cyclobutene dihydrate compound, having a chemical formula (I). ##STR00001## A method of synthesizing the tetracarbonyl cyclobutene dihydrate compound, includes: a synthesis step, a separation step, and a purification step. The synthesis step includes: collecting and dissolving 0.5728 g of squaric acid, 2.7948 g of ammonium formate, and 0.0480 g of the palladium complex in 100 mL of anhydrous methanol, heating and stirring a resulting mixture to reflux for 48 hrs, and stopping the reaction. The separation step includes: performing column chromatography analysis on reaction products according to a volume ratio of dichloromethane to anhydrous methanol of 8:2, to obtain a target product. A method of using the tetracarbonyl cyclobutene dihydrate compound, includes: using tetracarbonyl cyclobutene dihydrate compound as a catalyst in addition reaction between ethyl pyruvate and nitromethane, where a conversion rate of ethyl pyruvate reaches 96.1%.

The present invention relates to a process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides by reacting (a) cyclopropylcarbonitrile to a cyclopropylcarbaldehyde, (b) further reacting to a cyclobutanone, or (d) further reacting to an enamide, 5 (c) further reacting to enantiomerically and diastereomerically enriched cyclobutane amines, or (d) further reacting to an enamide and (e) to an enantiomerically and diastereomerically enriched cyclobutylamide to obtain (f) an enantiomerically and diastereomerically enriched cyclobutane amine, and (g) further reacting to an enantiomerically and diastereomerically enriched cyclobutane amide.