The present invention relates to a skin whitening cosmetic composition comprising verbenone as an active ingredient or a pharmaceutical composition for treating or preventing skin pigmentation disorders.

The present invention relates to a skin whitening cosmetic composition comprising verbenone as an active ingredient or a pharmaceutical composition for treating or preventing skin pigmentation disorders.

The present invention relates to a skin whitening cosmetic composition comprising verbenone as an active ingredient or a pharmaceutical composition for treating or preventing skin pigmentation disorders.

The present invention relates to a skin whitening cosmetic composition comprising verbenone as an active ingredient or a pharmaceutical composition for treating or preventing skin pigmentation disorders.

A process to isolate a compound of Formula (2a) or a salt or solvate thereof, comprising a) reacting a mixture of diastereoisomers of Formulae (2a, 2b) with a basic heterocyclic-aldehyde compound and an optically active amine in the presence of a base; and b) separating the compound of Formula (2a) from the product of step a) by acid extraction. The compound of Formula (2a) may be produced with an enantiomeric excess of 98%. Compounds of Formula (2a) are useful intermediates in a process to prepare a bicyclic -amino tetrazole derivative of Formula (I) which finds utility in treating neuropathic pain and disorders of the central nervous system.

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A process to isolate a compound of Formula (2a) or a salt or solvate thereof, comprising a) reacting a mixture of diastereoisomers of Formulae (2a, 2b) with a basic heterocyclic-aldehyde compound and an optically active amine in the presence of a base; and b) separating the compound of Formula (2a) from the product of step a) by acid extraction. The compound of Formula (2a) may be produced with an enantiomeric excess of 98%. Compounds of Formula (2a) are useful intermediates in a process to prepare a bicyclic -amino tetrazole derivative of Formula (I) which finds utility in treating neuropathic pain and disorders of the central nervous system.

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A process to isolate a compound of Formula (2a) or a salt or solvate thereof, comprising a) reacting a mixture of diastereoisomers of Formulae (2a, 2b) with a basic heterocyclic-aldehyde compound and an optically active amine in the presence of a base; and b) separating the compound of Formula (2a) from the product of step a) by acid extraction. The compound of Formula (2a) may be produced with an enantiomeric excess of 98%. Compounds of Formula (2a) are useful intermediates in a process to prepare a bicyclic -amino tetrazole derivative of Formula (I) which finds utility in treating neuropathic pain and disorders of the central nervous system.

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The present invention relates to novel compounds and their use as fragrance materials.

The present invention relates to novel compounds and their use as fragrance materials.