Disclosed are methods for preparing compound S-1 (S-1) from (R)-2-bromobutanoic acid prepared by treating (R)-2-aminobutanoic acid with an alkali metal nitrite compound and hydrobromic acid.

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Disclosed are methods for preparing compound S-1 (S-1) from (R)-2-bromobutanoic acid prepared by treating (R)-2-aminobutanoic acid with an alkali metal nitrite compound and hydrobromic acid.

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Disclosed is a method for preparing compound S-1 (S-1) comprising resolving compound rac-2 (rac-2) with a compound of Formula 3 wherein R.sup.1, R.sup.4, m and n are as defined in the disclosure.

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Disclosed is a method for preparing compound S-1 (S-1) comprising resolving compound rac-2 (rac-2) with a compound of Formula 3 wherein R.sup.1, R.sup.4, m and n are as defined in the disclosure.

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The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.

The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.

The present invention relates to derivatives of 10-methylene lipids, their preparation and their use.

The present invention relates to derivatives of 10-methylene lipids, their preparation and their use.

A process for producing a surfactant having two head groups and a single tail group per molecule, including steps of: producing a compound of Formula (1) from ethanol and carbon disulfide; producing a compound of Formula (2) from a carboxylic acid and bromine; producing a compound of Formula (3) from the compound of Formula (2) and methanol; producing a compound of Formula (4) from the compound of Formula (1) and the compound of Formula (3); and producing a compound of Formula (5) from the compound of Formula (4) by a direct oxidation process or by a peracid oxidation process. The surfactant produced by the process has lower critical micelle concentration and enables a lower surface tension of a liquid as compared with prior surfactants with two head groups per molecule, thereby enabling the amount of surfactant required and thus the cost to be substantially reduced.

A process for producing a surfactant having two head groups and a single tail group per molecule, including steps of: producing a compound of Formula (1) from ethanol and carbon disulfide; producing a compound of Formula (2) from a carboxylic acid and bromine; producing a compound of Formula (3) from the compound of Formula (2) and methanol; producing a compound of Formula (4) from the compound of Formula (1) and the compound of Formula (3); and producing a compound of Formula (5) from the compound of Formula (4) by a direct oxidation process or by a peracid oxidation process. The surfactant produced by the process has lower critical micelle concentration and enables a lower surface tension of a liquid as compared with prior surfactants with two head groups per molecule, thereby enabling the amount of surfactant required and thus the cost to be substantially reduced.