The present invention provides a method of preparing oxalic acid (H.sub.2C.sub.2O.sub.4), the method at least comprising the steps of: (a) providing a metal formate (HCO.sub.2M) containing stream, wherein the metal (M) of the metal formate (HCO.sub.2M) is a monovalent metal selected from the group consisting of Li, Na, K, Cs, Rb and a mixture thereof; (b) heating the metal formate (HCO.sub.2M) containing stream thereby obtaining a metal oxalate (M.sub.2C.sub.2O.sub.4) containing stream; (c) subjecting the metal oxalate (M.sub.2C.sub.2O.sub.4) containing stream to electrodialysis, thereby obtaining at least oxalic acid (M.sub.2C.sub.2O.sub.4) and a metal hydroxide (MOH).

The present invention provides a method of preparing oxalic acid (H.sub.2C.sub.2O.sub.4), the method at least comprising the steps of: (a) providing a metal formate (HCO.sub.2M) containing stream, wherein the metal (M) of the metal formate (HCO.sub.2M) is a monovalent metal selected from the group consisting of Li, Na, K, Cs, Rb and a mixture thereof; (b) heating the metal formate (HCO.sub.2M) containing stream thereby obtaining a metal oxalate (M.sub.2C.sub.2O.sub.4) containing stream; (c) subjecting the metal oxalate (M.sub.2C.sub.2O.sub.4) containing stream to electrodialysis, thereby obtaining at least oxalic acid (M.sub.2C.sub.2O.sub.4) and a metal hydroxide (MOH).

The present invention provides solid forms of compound (1) and compositions thereof which are useful as inhibitors of Plasma Kallikrein (pKal) and which exhibit desirable characteristics for the same.

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The present invention provides solid forms of compound (1) and compositions thereof which are useful as inhibitors of Plasma Kallikrein (pKal) and which exhibit desirable characteristics for the same.

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The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.

The present invention relates to a process suitable for adoption to large scale manufacture of 1-isopropyl-3-{5-[1-(3-methoxypropyl)piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-1H-indazole oxalate of formula (I), which is a selective 5-HT.sub.4 receptor ligand intended for the symptomatic treatment of Alzheimer's disease and other disorders of memory and cognition like Attention deficient hyperactivity, Parkinson's and Schizophrenia.

The present invention relates to a process suitable for adoption to large scale manufacture of 1-isopropyl-3-{5-[1-(3-methoxypropyl)piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-1H-indazole oxalate of formula (I), which is a selective 5-HT.sub.4 receptor ligand intended for the symptomatic treatment of Alzheimer's disease and other disorders of memory and cognition like Attention deficient hyperactivity, Parkinson's and Schizophrenia.

The present invention relates to a process suitable for adoption to large scale manufacture of 1-isopropyl-3-{5-[1-(3-methoxypropyl)piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-1H-indazole oxalate of formula (I), which is a selective 5-HT.sub.4 receptor ligand intended for the symptomatic treatment of Alzheimer's disease and other disorders of memory and cognition like Attention deficient hyperactivity, Parkinson's and Schizophrenia.

A method of selectively removing impurities from a scandium-containing feed solution includes contacting an aqueous scandium-containing solution with an organic solvent stream containing an extractant, thereby forming a loaded organic solvent stream containing the impurity or impurities while leaving the scandium in the raffinate. The aqueous stream containing the scandium is washed, diluted and has inorganic salts added before being contacted with a second organic solvent stream to extract the scandium selectively, and followed by stripping the scandium from the scandium-containing loaded organic extractant stream by adding oxalic acid to the loaded organic extractant stream to form scandium oxalate.

A method of selectively removing impurities from a scandium-containing feed solution includes contacting an aqueous scandium-containing solution with an organic solvent stream containing an extractant, thereby forming a loaded organic solvent stream containing the impurity or impurities while leaving the scandium in the raffinate. The aqueous stream containing the scandium is washed, diluted and has inorganic salts added before being contacted with a second organic solvent stream to extract the scandium selectively, and followed by stripping the scandium from the scandium-containing loaded organic extractant stream by adding oxalic acid to the loaded organic extractant stream to form scandium oxalate.