The multifunctional compound is represented by formula X—C(R)RF—Y, in which X and Y are each independently —C(O)—O-M, —C(O)-HAL, —C(O)—NR.sup.1.sub.2, —C≡N, —C(O)NR.sup.1—SO.sub.2—R.sub.f.sup.1-W, or a fluorinated alkenyl group that is optionally interrupted by one or more —O— groups. HAL is —F, —Cl, or —Br. R.sub.f.sup.1 is a fluorinated alkylene group that is optionally interrupted by one or more —O— groups. W is —F, —SO.sub.2Z, —CF═CF.sub.2, —O—CF═CF.sub.2, or —O—CF.sub.2—CF═CF.sub.2. Z is —F, —Cl, —NR.sup.1.sub.2, or —OM. Each R.sup.1 is a hydrogen atom or alkyl having up to four carbon atoms. M is an alkyl group, a trimethylsilyl group, a hydrogen atom, a metallic cation, or a quaternary ammonium cation. R is a bromine, chloride, fluorine or hydrogen atom; and RF is a fluorinated alkenyl group that is unsubstituted or substituted by at least one chlorine atom, aryl group, or a combination thereof or RF is a fluorinated alkyl group or arylalkylenyl group that is substituted by bromine or iodine and uninterrupted or interrupted by at least one —O— group. A process for making the compound is also disclosed. A fluoropolymer made from the compound and a method of making the fluoropolymer are also disclosed.

The multifunctional compound is represented by formula X—C(R)RF—Y, in which X and Y are each independently —C(O)—O-M, —C(O)-HAL, —C(O)—NR.sup.1.sub.2, —C≡N, —C(O)NR.sup.1—SO.sub.2—R.sub.f.sup.1-W, or a fluorinated alkenyl group that is optionally interrupted by one or more —O— groups. HAL is —F, —Cl, or —Br. R.sub.f.sup.1 is a fluorinated alkylene group that is optionally interrupted by one or more —O— groups. W is —F, —SO.sub.2Z, —CF═CF.sub.2, —O—CF═CF.sub.2, or —O—CF.sub.2—CF═CF.sub.2. Z is —F, —Cl, —NR.sup.1.sub.2, or —OM. Each R.sup.1 is a hydrogen atom or alkyl having up to four carbon atoms. M is an alkyl group, a trimethylsilyl group, a hydrogen atom, a metallic cation, or a quaternary ammonium cation. R is a bromine, chloride, fluorine or hydrogen atom; and RF is a fluorinated alkenyl group that is unsubstituted or substituted by at least one chlorine atom, aryl group, or a combination thereof or RF is a fluorinated alkyl group or arylalkylenyl group that is substituted by bromine or iodine and uninterrupted or interrupted by at least one —O— group. A process for making the compound is also disclosed. A fluoropolymer made from the compound and a method of making the fluoropolymer are also disclosed.

An object of the present invention is to provide a method for stabilizing an acrylic acid derivative, and a composition containing an acrylic acid derivative in which the acrylic acid derivative is stabilized. The present invention provides a composition comprising: (A) an acrylic acid derivative represented by Formula (I): ##STR00001##
(wherein, R.sup.1 and R.sup.2 are the same or different, and each represents alkyl, fluoroalkyl, aryl that may have one or more substituents, halogen, or hydrogen; R.sup.c represents a group: OR.sup.3 (wherein R.sup.3 represents alkyl, fluoroalkyl, aryl that may have one or more substituents, or hydrogen) or halogen; and X represents fluoroalkyl, alkyl, hydrogen, or halogen); and (B) amide, wherein the content of acrylic acid derivative (A) is 30% (w/w) or more.

An object of the present invention is to provide a method for stabilizing an acrylic acid derivative, and a composition containing an acrylic acid derivative in which the acrylic acid derivative is stabilized. The present invention provides a composition comprising: (A) an acrylic acid derivative represented by Formula (I): ##STR00001##
(wherein, R.sup.1 and R.sup.2 are the same or different, and each represents alkyl, fluoroalkyl, aryl that may have one or more substituents, halogen, or hydrogen; R.sup.c represents a group: OR.sup.3 (wherein R.sup.3 represents alkyl, fluoroalkyl, aryl that may have one or more substituents, or hydrogen) or halogen; and X represents fluoroalkyl, alkyl, hydrogen, or halogen); and (B) amide, wherein the content of acrylic acid derivative (A) is 30% (w/w) or more.

An object of the present invention is to provide a method for stabilizing an acrylic acid derivative, and a composition containing an acrylic acid derivative in which the acrylic acid derivative is stabilized. The present invention provides a composition comprising: (A) an acrylic acid derivative represented by Formula (I): ##STR00001##
(wherein, R.sup.1 and R.sup.2 are the same or different, and each represents alkyl, fluoroalkyl, aryl that may have one or more substituents, halogen, or hydrogen; R.sup.c represents a group: OR.sup.3 (wherein R.sup.3 represents alkyl, fluoroalkyl, aryl that may have one or more substituents, or hydrogen) or halogen; and X represents fluoroalkyl, alkyl, hydrogen, or halogen); and (B) amide, wherein the content of acrylic acid derivative (A) is 30% (w/w) or more.

The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2):

##STR00001##

wherein R is a fluorine atom or a methoxy group, and R.sup.400 is a hydrogen atom or a C.sub.1-C.sub.4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.

The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2):

##STR00001##

wherein R is a fluorine atom or a methoxy group, and R.sup.400 is a hydrogen atom or a C.sub.1-C.sub.4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.

An object of the present invention is to provide a method for stabilizing an acrylic acid derivative, and a composition containing an acrylic acid derivative in which the acrylic acid derivative is stabilized. The present invention provides a composition comprising: (A) an acrylic acid derivative represented by Formula (I):

##STR00001##

(wherein, R.sup.1 and R.sup.2 are the same or different, and each represents alkyl, fluoroalkyl, aryl that may have one or more substituents, halogen, or hydrogen; R.sup.c represents a group: OR.sup.3 (wherein R.sup.3 represents alkyl, fluoroalkyl, aryl that may have one or more substituents, or hydrogen) or halogen; and X represents fluoroalkyl, alkyl, hydrogen, or halogen); and (B) amide, wherein the content of acrylic acid derivative (A) is 30% (w/w) or more.

An object of the present invention is to provide a method for stabilizing an acrylic acid derivative, and a composition containing an acrylic acid derivative in which the acrylic acid derivative is stabilized. The present invention provides a composition comprising: (A) an acrylic acid derivative represented by Formula (I):

##STR00001##

(wherein, R.sup.1 and R.sup.2 are the same or different, and each represents alkyl, fluoroalkyl, aryl that may have one or more substituents, halogen, or hydrogen; R.sup.c represents a group: OR.sup.3 (wherein R.sup.3 represents alkyl, fluoroalkyl, aryl that may have one or more substituents, or hydrogen) or halogen; and X represents fluoroalkyl, alkyl, hydrogen, or halogen); and (B) amide, wherein the content of acrylic acid derivative (A) is 30% (w/w) or more.

An object of the present invention is to provide a method for stabilizing an acrylic acid derivative, and a composition containing an acrylic acid derivative in which the acrylic acid derivative is stabilized. The present invention provides a composition comprising: (A) an acrylic acid derivative represented by Formula (I):

##STR00001##

(wherein, R.sup.1 and R.sup.2 are the same or different, and each represents alkyl, fluoroalkyl, aryl that may have one or more substituents, halogen, or hydrogen; R.sup.c represents a group: OR.sup.3 (wherein R.sup.3 represents alkyl, fluoroalkyl, aryl that may have one or more substituents, or hydrogen) or halogen; and X represents fluoroalkyl, alkyl, hydrogen, or halogen); and (B) amide, wherein the content of acrylic acid derivative (A) is 30% (w/w) or more.