Methods for syntheses of organic acids from α-keto acids, including methods for syntheses of isotopically enriched organic acids from α-keto acids are disclosed. The isotopically enriched organic acids are useful, for example, in metabolic flux analyses.

Methods for syntheses of organic acids from α-keto acids, including methods for syntheses of isotopically enriched organic acids from α-keto acids are disclosed. The isotopically enriched organic acids are useful, for example, in metabolic flux analyses.

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

The invention relates to pharmaceutical uses of compounds of formula (II). Particular aspects of the invention relate to the use of those compounds in treating, preventing or ameliorating a seizure-related disorder, bipolar disorder, mania, migraine, Alzheimer's disease, Parkinson's disease or stroke.

The invention relates to pharmaceutical uses of compounds of formula (II). Particular aspects of the invention relate to the use of those compounds in treating, preventing or ameliorating a seizure-related disorder, bipolar disorder, mania, migraine, Alzheimer's disease, Parkinson's disease or stroke.

Method for extracting ferulic acid and/or its salts from a previously conditioned source rich in ferulic acid and its salts which comprises adsorbing the ferulic acid and/or its salts on a column packed with synthetic resin, desorbing the ferulic acid and/or its salts using an organic solvent, separating the liquor rich in ferulic acid into two fractions according to their water content, separately concentrating the two liquor fractions, mixing and concentrating said fractions, adding 2 volumes of water to them, concentrating the mixture obtained, separating out the insoluble impurities by sedimentation, pre-crystallizing the ferulic acid and/or its salts with a synthetic purification resin, crystallizing out the ferulic acid and/or its salts, separating the ferulic acid and/or its salts from the crystallization mother liquors and drying it and screening it.

Method for extracting ferulic acid and/or its salts from a previously conditioned source rich in ferulic acid and its salts which comprises adsorbing the ferulic acid and/or its salts on a column packed with synthetic resin, desorbing the ferulic acid and/or its salts using an organic solvent, separating the liquor rich in ferulic acid into two fractions according to their water content, separately concentrating the two liquor fractions, mixing and concentrating said fractions, adding 2 volumes of water to them, concentrating the mixture obtained, separating out the insoluble impurities by sedimentation, pre-crystallizing the ferulic acid and/or its salts with a synthetic purification resin, crystallizing out the ferulic acid and/or its salts, separating the ferulic acid and/or its salts from the crystallization mother liquors and drying it and screening it.

The technology disclosed herein concerns a family of alkoxybenzophenones for use as photoinitiators for crosslinking polyolefins.

The technology disclosed herein concerns a family of alkoxybenzophenones for use as photoinitiators for crosslinking polyolefins.

A method of identifying a Mycobacterium using surface enhanced Raman spectroscopy (SERS), disclosed herein, comprises disposing a sample suspected to comprise a Mycobacterium on a SERS-active substrate, detecting surface enhanced Raman signals corresponding to an alpha-mycolic acid, a methoxy-mycolic acid, and a keto-mycolic acid from the sample disposed on the SERS-active substrate, and determining one or more ratios of intensity of the surface enhanced Raman signals to identify the Mycobacterium. Disclosed herein also includes a method of detecting a mycobacterial disease using surface enhanced Raman spectroscopy (SERS), the method comprising identifying a Mycobacterium according to the method described above, and determining the mycobacterial disease based on the Mycobacterium identified.