Methods and processes for preparing calcium salts of alpha-ketoglutarate are described herein.

The present disclosure relates to crystalline forms of N-{3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-allylidene}-aminoguanidinium salts having high solubility. The disclosure also relates to use of said crystalline forms in medicine.

A sulfonic acid or carboxylic acid containing a carbonyl group, or a salt thereof represented by the following formula:
R.sup.1—C(═O)—(CR.sup.2.sub.2).sub.n—(OR.sup.3).sub.p—(CR.sup.4.sub.2).sub.q-L-A
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, n, p, q, A and L are as defined herein.

A sulfonic acid or carboxylic acid containing a carbonyl group, or a salt thereof represented by the following formula:
R.sup.1—C(═O)—(CR.sup.2.sub.2).sub.n—(OR.sup.3).sub.p—(CR.sup.4.sub.2).sub.q-L-A
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, n, p, q, A and L are as defined herein.

The present invention relates to novel pharmaceutically acceptable salts of Bempedoic acid, novel intermediates of Bempedoic acid, novel crystalline form of Bempedoic acid and novel processes for the preparation of Bempedoic acid or its intermediates thereof.

The present invention relates to novel pharmaceutically acceptable salts of Bempedoic acid, novel intermediates of Bempedoic acid, novel crystalline form of Bempedoic acid and novel processes for the preparation of Bempedoic acid or its intermediates thereof.

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoroanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture. ##STR00001##

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoroanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture. ##STR00001##

Methods for syntheses of organic acids from -keto acids, including methods for syntheses of isotopically encriched organic acids from -keto acids are disclosed. The isotopically enriched organic acids are useful, for example, in metabolic flux analyses.

Methods for syntheses of organic acids from -keto acids, including methods for syntheses of isotopically encriched organic acids from -keto acids are disclosed. The isotopically enriched organic acids are useful, for example, in metabolic flux analyses.