A process to prepare a compound of Formula (I) ##STR00001##
wherein R.sup.3, R.sup.4 and R.sup.5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.

The present disclosure provides a process for the preparation of compounds of formula (III),

##STR00001##

compounds of formula (V),

##STR00002##

and corresponding salts of formula (IV).

##STR00003##

The compounds made by the methods and processes of the invention are particularly useful for administration in humans and animals.

The present disclosure provides a process for the preparation of compounds of formula (III),

##STR00001##

compounds of formula (V),

##STR00002##

and corresponding salts of formula (IV).

##STR00003##

The compounds made by the methods and processes of the invention are particularly useful for administration in humans and animals.

To provide a polar compound having high chemical stability, a high ability to align liquid crystal molecules, and high solubility in a liquid crystal composition, and a high voltage holding ratio of a liquid crystal display element.

A compound represented by Formula (1):

##STR00001## R.sup.1 is a hydrogen atom or an alkyl group that may be substituted; a is 2 to 12; and R.sup.2 is Formula (1-a), Formula (1-b), and Formula (1-c);

##STR00002## Sp.sup.1 to Sp.sup.3 are a single bond or an alkylene group that may be substituted; M.sup.1 and M.sup.2 are H, F, Cl, or an alkyl group that may be substituted; and X.sup.1 is OH, NH.sub.2, OR.sup.3, N(R.sup.3).sub.2, COOH, SH or Si(R.sup.3).sub.3.

To provide a polar compound having high chemical stability, a high ability to align liquid crystal molecules, and high solubility in a liquid crystal composition, and a high voltage holding ratio of a liquid crystal display element.

A compound represented by Formula (1):

##STR00001## R.sup.1 is a hydrogen atom or an alkyl group that may be substituted; a is 2 to 12; and R.sup.2 is Formula (1-a), Formula (1-b), and Formula (1-c);

##STR00002## Sp.sup.1 to Sp.sup.3 are a single bond or an alkylene group that may be substituted; M.sup.1 and M.sup.2 are H, F, Cl, or an alkyl group that may be substituted; and X.sup.1 is OH, NH.sub.2, OR.sup.3, N(R.sup.3).sub.2, COOH, SH or Si(R.sup.3).sub.3.

The invention relates to lipid compounds of formula f(1) and their pharmaceutically acceptable salts for the prevention and/or treatment of ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases: (I) (wherein R.sup.1 is either a C.sub.9 to C.sub.22 alkyl group, or a C.sub.9 to C.sub.22 alkenyl group having from 1 to 6 double bonds; R.sup.2 is selected from the group consisting of a halogen atom, a hydroxy group, an alkyl group, an alkoxy group, an alkylthio group, a carboxy group, an acyl group, an amino group, and an alkylamino group; R.sup.3 is a hydrogen atom, or a group R.sup.2; R.sup.4 is a carboxylic acid or a derivative thereof; and X is methylene (CH.sub.2), or an oxygen or sulfur atom).

The invention relates to lipid compounds of formula f(1) and their pharmaceutically acceptable salts for the prevention and/or treatment of ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases: (I) (wherein R.sup.1 is either a C.sub.9 to C.sub.22 alkyl group, or a C.sub.9 to C.sub.22 alkenyl group having from 1 to 6 double bonds; R.sup.2 is selected from the group consisting of a halogen atom, a hydroxy group, an alkyl group, an alkoxy group, an alkylthio group, a carboxy group, an acyl group, an amino group, and an alkylamino group; R.sup.3 is a hydrogen atom, or a group R.sup.2; R.sup.4 is a carboxylic acid or a derivative thereof; and X is methylene (CH.sub.2), or an oxygen or sulfur atom).

A process to prepare a compound of Formula (I)

##STR00001##

wherein R.sup.3, R.sup.4 and R.sup.5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.

A process to prepare a compound of Formula (I)

##STR00001##

wherein R.sup.3, R.sup.4 and R.sup.5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.

The present disclosure provides a process for the preparation of compounds of formula (III), ##STR00001##
compounds of formula (V), ##STR00002##
and corresponding salts of formula (IV). ##STR00003## The compounds made by the methods and processes of the invention are particularly useful for administration in humans and animals.