Process for the production of methylidene malonates and cyanoacrylates employing in-situ formed iminium salts derived from acid halides and/or acid anhydrides and N,N,N′,N′-tetra hydrocarbyl diaminoalkanes, the acid halides and/or acid anhydrides being present in a molar excess relative to the diaminoalkanes, as co-reactants with select malonic acid esters and cyanoacetates, respectively.

Process for the production of methylidene malonates and cyanoacrylates employing in-situ formed iminium salts derived from acid halides and/or acid anhydrides and N,N,N′,N′-tetra hydrocarbyl diaminoalkanes, the acid halides and/or acid anhydrides being present in a molar excess relative to the diaminoalkanes, as co-reactants with select malonic acid esters and cyanoacetates, respectively.

Described herein are methods and devices that allow the generation of [F-18]triflyl fluoride and other [F-18] sulfonyl fluorides (such as [F-18]tosyl fluoride) in a manner that is suitable for radiosynthesis of F-18 labeled radiopharmaceuticals using currently available synthesis modules.

Described herein are methods and devices that allow the generation of [F-18]triflyl fluoride and other [F-18] sulfonyl fluorides (such as [F-18]tosyl fluoride) in a manner that is suitable for radiosynthesis of F-18 labeled radiopharmaceuticals using currently available synthesis modules.

Disclosed is a method for producing an acrylic acid derivative represented by formula (1):

##STR00001##

wherein R.sup.1 represents hydrogen or the like; R.sup.3 represents hydrogen or the like; and X represents hydrogen or the like, the method comprising step B of bringing an organic metal compound represented by formula (A3A): wherein R.sup.2, in each occurrence, is the same or different and represents hydrogen or like; R.sup.3 represents hydrogen or the like; X represents hydrogen or the like; and M represents hydrogen or the like, or an organic metal compound represented by formula (A3B): wherein the symbols are as defined above, or a combination thereof, into contact with a proton donor and an aldehyde compound to obtain a compound represented by formula (1).

Disclosed is a method for producing an acrylic acid derivative represented by formula (1):

##STR00001##

wherein R.sup.1 represents hydrogen or the like; R.sup.3 represents hydrogen or the like; and X represents hydrogen or the like, the method comprising step B of bringing an organic metal compound represented by formula (A3A): wherein R.sup.2, in each occurrence, is the same or different and represents hydrogen or like; R.sup.3 represents hydrogen or the like; X represents hydrogen or the like; and M represents hydrogen or the like, or an organic metal compound represented by formula (A3B): wherein the symbols are as defined above, or a combination thereof, into contact with a proton donor and an aldehyde compound to obtain a compound represented by formula (1).

The invention relates to processes for preparing benzoprostacyclin analogues and intermediates prepared from the process, and the benzoprostacyclin analogues prepared therefrom. The invention also relates to cyclopentenone intermediates in racemic or optically active form.

The invention relates to processes for preparing benzoprostacyclin analogues and intermediates prepared from the process, and the benzoprostacyclin analogues prepared therefrom. The invention also relates to cyclopentenone intermediates in racemic or optically active form.

Methods of preparing unsaturated compounds or analogs through dehydrogenation of corresponding saturated compounds and/or hydrogenation of aromatic compounds are disclosed.

Methods of preparing unsaturated compounds or analogs through dehydrogenation of corresponding saturated compounds and/or hydrogenation of aromatic compounds are disclosed.