A process for the synthesis of N-alkylated lactams via reductive alkylation. The process of the present disclosure may be conducted by the addition of an aldehyde to a lactam in the presence of a catalyst under a reducing atmosphere.

A process for the synthesis of N-alkylated lactams via reductive alkylation. The process of the present disclosure may be conducted by the addition of an aldehyde to a lactam in the presence of a catalyst under a reducing atmosphere.

There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.

There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.

A process for the synthesis of N-alkylated lactams via reductive alkylation. The process of the present disclosure may be conducted by the addition of an aldehyde to a lactam in the presence of a catalyst under a reducing atmosphere.

The present invention relates to a process for preparing C.sub.4-C.sub.15 lactams, in which a C.sub.1-C.sub.10-alkyl nitrite is reacted with a C.sub.4-C.sub.15-cycloalkane and is illuminated with a light-emitting diode during the reaction. This forms a C.sub.4-C.sub.15-cyclohexanone oxime which is then converted further to a C.sub.4-C.sub.15 lactam; the C.sub.1-C.sub.10 alcohol formed is recycled into the preparation of the C.sub.1-C.sub.10-alkyl nitrite.

The present invention relates to a process for preparing C.sub.4-C.sub.15 lactams, in which a C.sub.1-C.sub.10-alkyl nitrite is reacted with a C.sub.4-C.sub.15-cycloalkane and is illuminated with a light-emitting diode during the reaction. This forms a C.sub.4-C.sub.15-cyclohexanone oxime which is then converted further to a C.sub.4-C.sub.15 lactam; the C.sub.1-C.sub.10 alcohol formed is recycled into the preparation of the C.sub.1-C.sub.10-alkyl nitrite.

The present invention relates to novel methods for preparing cis-alkoxy-substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and also to novel intermediates and starting compounds, which are passed through or used in the method according to the invention.

The present invention relates to novel methods for preparing cis-alkoxy-substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and also to novel intermediates and starting compounds, which are passed through or used in the method according to the invention.

The present invention relates to novel methods for preparing cis-alkoxy-substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and also to novel intermediates and starting compounds, which are passed through or used in the method according to the invention.