The present invention relates to methods for controlling or preventing infestation of cereal plants by the phytopathogenic microorganism Fusarium pseudograminearum, comprising applying to a crop of plants, the locus thereof, or seed thereof, a compound according to formula (I) wherein R1, R2, R3, R4, R5, Y, A, B are as defined herein.

##STR00001##

The invention relates to a novel substituted amino acids, agricultural compositions comprising the novel substituted amino acids, and their use for controlling undesired plant growth alone or in combination with crop protection agents such as pesticides or plant growth regulators.

Compounds of formula I are provided:

##STR00001##

wherein X is NH, or CH.sub.2, Y is a single bond, or —CHR.sub.5—, R.sub.1 is H, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 hydroxyalkyl, R.sub.2 and R.sub.2′ are each independently H, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 hydroxyalkyl, each R.sub.3 is independently H, halo, —CF.sub.3, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 alkoxy, C.sub.3 perhaloalkyl, each R.sub.4 is independently H, halo, or C.sub.1-C.sub.4 alkyl, R.sub.5 is C.sub.1-C.sub.4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.

Compounds of formula I are provided:

##STR00001##

wherein X is NH, or CH.sub.2, Y is a single bond, or —CHR.sub.5—, R.sub.1 is H, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 hydroxyalkyl, R.sub.2 and R.sub.2′ are each independently H, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 hydroxyalkyl, each R.sub.3 is independently H, halo, —CF.sub.3, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 alkoxy, C.sub.3 perhaloalkyl, each R.sub.4 is independently H, halo, or C.sub.1-C.sub.4 alkyl, R.sub.5 is C.sub.1-C.sub.4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.

The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

A family of novel diazirine-based molecules as well as methods of manufacture and uses thereof are disclosed. These compounds allow non-functionalized polymers, such as polyolefins, to crosslink via C—H insertion. Such a C—H insertion process is useful, for example, for forming protective topical coatings on low surface energy films, for the covalent adhesive bonding of such films, or for creating rigid 3-dimenional polymeric structures by in-situ doping and activation of the crosslinker. The crosslinkers can be activated thermally, by UV radiation or by an electric potential.

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA. ##STR00001##