This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

The instant invention relates to compounds of formula I

##STR00001## wherein: R is selected from H, Me or Cl, and R′ is selected from: H, NH.sub.2, NHCOCH.sub.3 NHCOCF.sub.3 or NHCOCH.sub.2Cl. The invention further provides a process for obtaining the compounds of formula I and their use.

The instant invention relates to compounds of formula I

##STR00001## wherein: R is selected from H, Me or Cl, and R′ is selected from: H, NH.sub.2, NHCOCH.sub.3 NHCOCF.sub.3 or NHCOCH.sub.2Cl. The invention further provides a process for obtaining the compounds of formula I and their use.

The instant invention describes hydrazide-containing compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.

The instant invention describes hydrazide-containing compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.

Provided herein are, inter alia, methods of treating cancer using compounds of the invention.

The present invention provides a compound having the structure:

##STR00001##

and use of the compound for inhibiting the growth of or killing

This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.