The present invention relates to novel herbicidally active, substituted 1,5-diphenylpyrazolyl-3-oxyalkyl acids and 1-phenyl-5-thienylpyrazolyl-3-oxyalkyl acids and derivatives thereof according to the general formula (I) or agrochemically acceptable salts thereof, to processes for preparation thereof and to the use thereof for control of broadleaved weeds and weed grasses in crops of useful plants and for general control of broadleaved weeds and weed grasses in areas of the environment where plant growth is troublesome. The derivatives of the 1,5-diphenylpyrazolyl-3-oxyalkyl acids and 1-phenyl-5-thienylpyrazolyl-3-oxyalkyl acids especially include the esters, salts and amides thereof.

A pharmaceutical preparation comprising {circle around (−)} A2-73 substantially free of ⊕ A2-73. This invention further includes a method treating Alzheimer's disease in a subject in need of such treatment by the method of administering a therapeutically effective amount of {circle around (−)} A2-73 substantially free of ⊕ A2-73. This invention yet further includes a method of classifying cells as to sigma receptor type by the method of exposing said cells to a detectable amount of {circle around (−)} A2-73 substantially free of ⊕ A2-73 and determining the level of sigma receptor binding.

A pharmaceutical preparation comprising {circle around (−)} A2-73 substantially free of ⊕ A2-73. This invention further includes a method treating Alzheimer's disease in a subject in need of such treatment by the method of administering a therapeutically effective amount of {circle around (−)} A2-73 substantially free of ⊕ A2-73. This invention yet further includes a method of classifying cells as to sigma receptor type by the method of exposing said cells to a detectable amount of {circle around (−)} A2-73 substantially free of ⊕ A2-73 and determining the level of sigma receptor binding.

Novel active compound combinations comprising a carboxamide of the general formula (I) (group 1) ##STR00001##
in which
A, R.sup.1, R.sup.2 and R.sup.3 are as defined in the description,
and the active compound groups (2) to (23) listed in the description have very good fungicidal properties.

Novel active compound combinations comprising a carboxamide of the general formula (I) (group 1) ##STR00001##
in which
A, R.sup.1, R.sup.2 and R.sup.3 are as defined in the description,
and the active compound groups (2) to (23) listed in the description have very good fungicidal properties.

Imidazolone and pyrazolone derivatives of formula (I) described herein exhibit human neutrophil elastase inhibitory properties and are useful for the therapy of diseases and conditions in which HNE is implicated.

The present invention provides compounds of Formula (I): ##STR00001##
or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity/weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory/autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and drug resistant cancer of various types.

The present application relates to the use of heterocyclic compounds for controlling animal pests including arthropods, insects and nematodes, to novel heterocyclic compounds, to processes for their preparation and to intermediates for preparing the heterocyclic compounds.

The present application relates to the use of heterocyclic compounds for controlling animal pests including arthropods, insects and nematodes, to novel heterocyclic compounds, to processes for their preparation and to intermediates for preparing the heterocyclic compounds.